Show simple item record

dc.contributor.authorKeil, Deborah E.
dc.contributor.authorBuck, Brenda
dc.contributor.authorGoossens, Dirk
dc.contributor.authorMcLaurin, Brett
dc.contributor.authorMurphy, Lacey M.
dc.contributor.authorLeetham-Spencer, Mallory
dc.contributor.authorTeng, Yuanxin
dc.contributor.authorPollard, James
dc.contributor.authorGerads, Russell
dc.contributor.authorDeWitt, Jamie C.
dc.date.accessioned2018-09-14T21:21:45Z
dc.date.available2018-09-14T21:21:45Z
dc.date.issued2018
dc.identifier.citationKeil, D. E., Buck, B., Goossens, D., McLaurin, B., Murphy, L., Leetham-Spencer, M., … DeWitt, J. C. (2018). Nevada desert dust with heavy metals suppresses IgM antibody production. Toxicology Reports, 5, 258–269. doi:10.1016/j.toxrep.2018.01.006en_US
dc.identifier.issn2214-7500
dc.identifier.urihttps://scholarworks.montana.edu/xmlui/handle/1/14837
dc.description.abstractSystemic health effects from exposure to a complex natural dust containing heavy metalsfrom the Nellis Dunes Recreation Area (NDRA) near Las Vegas, NV, were evaluated. Several toxicological parameters were examined following lung exposure to emissive dust from three geologic sediment types heavily used for recreational off-road activities: yellow sand very rich in arsenic (termed CBN 5); a shallow cover of loose dune sand overlying a gravelly subsoil bordering dune fields (termed CBN 6); and brown claystone and siltstone(termed CBN 7). Adult female B6C3F1 mice were exposed by oropharyngeal administration to these three types of geogenic dusts at 0.01–100 mg of dust/kg of body weight, once per week for four weeks. The median grain sizes were 4.6, 3.1, and 4.4 μm, for CBN 5, 6, and 7, respectively. Each type of dust contained quantifiable amounts of aluminum, vanadium, chromium, manganese, iron, cobalt, copper, zinc, arsenic, strontium, cesium, lead, uranium, and others. Descriptive markers of immunotoxicity, neurotoxicity, hematology, and clinical chemistry parameters were assessed. Notable among all three CBN units was a systemic, dose-responsive decrease in antigen-specific IgM antibody responses. Geogenic dust from CBN 5 produced more than a 70% suppression in IgM responses, establishing a lowest adverse effect level (LOAEL) of 0.01 mg/kg. A suppression in IgM responses and a corresponding increase in serum creatinine determined a LOAEL of 0.01 mg/kg for CBN 6. The LOAEL for CBN 7 was 0.1 mg/kg and also was identified from suppression in IgM responses. These results are of concern given the frequent off-road vehicle traffic and high visitor rates at the NDRA, estimated at 300,000 each year.en_US
dc.language.isoenen_US
dc.rightsCC BY-NC-ND, This license is the most restrictive of our six main licenses, only allowing you to download this work and share it with others as long as you credit the original creator, but you can’t change the work in any way or use it commercially.en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/legalcodeen_US
dc.titleNevada Dust with Metals suppresses IgM antibodiesen_US
dc.typeArticleen_US
mus.citation.extentfirstpage258en_US
mus.citation.extentlastpage269en_US
mus.citation.journaltitleToxicology Reportsen_US
mus.citation.volume5en_US
mus.identifier.categoryHealth & Medical Sciencesen_US
mus.identifier.doi10.1016/j.toxrep.2018.01.006en_US
mus.relation.collegeCollege of Letters & Scienceen_US
mus.relation.departmentMicrobiology & Immunology.en_US
mus.relation.universityMontana State University - Bozemanen_US
mus.data.thumbpage8en_US
mus.contributor.orcidKeil, Deborah E.|0000-0002-5787-8514en_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

CC BY-NC-ND, This license is the most restrictive of our six main licenses, only allowing you to download this work and share it with others as long as you credit the original creator, but you can’t change the work in any way or use it commercially.
Except where otherwise noted, this item's license is described as CC BY-NC-ND, This license is the most restrictive of our six main licenses, only allowing you to download this work and share it with others as long as you credit the original creator, but you can’t change the work in any way or use it commercially.

MSU uses DSpace software, copyright © 2002-2017  Duraspace. For library collections that are not accessible, we are committed to providing reasonable accommodations and timely access to users with disabilities. For assistance, please submit an accessibility request for library material.