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dc.contributor.authorLei, Benfang
dc.contributor.authorMinor, Dylan
dc.contributor.authorFeng, Wenchao
dc.contributor.authorLiu, Mengyao
dc.date.accessioned2018-11-19T17:52:36Z
dc.date.available2018-11-19T17:52:36Z
dc.date.issued2018-06
dc.identifier.citationLei, Benfang, Dylan Minor, Wenchao Feng, and Mengyao Liu. "Hypervirulent Group A Streptococcus of Genotype emm3 Invades the Vascular System in Pulmonary Infection of Mice." Infection & Immunity 86, no. 6 (June 2018): e00080-18. DOI:10.1128/IAI.00080-18.en_US
dc.identifier.issn0019-9567
dc.identifier.urihttps://scholarworks.montana.edu/xmlui/handle/1/15017
dc.description.abstractNatural mutations of the two-component regulatory system CovRS are frequently associated with invasive Group A Streptococcus (GAS) isolates and lead to the enhancement in virulence gene expression, innate immune evasion, systemic dissemination, and virulence. How CovRS mutations enhance systemic dissemination is not well understood. A hypervirulent GAS isolate of the emm3 genotype, MGAS315, was characterized using a mouse model of pulmonary infection to understand systemic dissemination. This strain has a G1370T mutation in the sensor kinase covS gene of CovRS. Intratracheal inoculation of MGAS315 led to the lung infection that displayed extensive Gram staining at the alveolar ducts, alveoli, and peribronchovascular and perivascular interstitium. The correction of the covS mutation did not alter the infection at the alveolar ducts and alveoli but prevented GAS invasion of the peribronchovascular and perivascular interstitium. Furthermore, the covS mutation allowed MGAS315 to disrupt and degrade the smooth muscle and endothelial layers of the blood vessels, directly contributing to systemic dissemination. It is concluded that hypervirulent emm3 GAS covS mutants can invade the perivascular interstitium and directly attack the vascular system for systemic dissemination.en_US
dc.language.isoenen_US
dc.rightsThis Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).en_US
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en_US
dc.titleHypervirulent Group A Streptococcus of Genotype emm3 Invades the Vascular System in Pulmonary Infection of Miceen_US
dc.typeArticleen_US
mus.citation.issue6en_US
mus.citation.journaltitleInfection & Immunityen_US
mus.citation.volume86en_US
mus.identifier.categoryHealth & Medical Sciencesen_US
mus.identifier.doi10.1128/IAI.00080-18en_US
mus.relation.collegeCollege of Letters & Scienceen_US
mus.relation.departmentMicrobiology & Immunology.en_US
mus.relation.universityMontana State University - Bozemanen_US
mus.data.thumbpage9en_US


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