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dc.contributor.authorCatto, C.
dc.contributor.authorJames, Garth A.
dc.contributor.authorVilla, Federica
dc.contributor.authorVilla, S.
dc.contributor.authorCappitelli, Francesca
dc.identifier.citationCatto, C., Garth James, F. Villa, S. Villa, and F. Cappitelli. "Zosteric acid and salicylic acid bound to a low density polyethylene surface successfully control bacterial biofilm formation." Biofouling 34, no. 4 (April 2018): 440-452. DOI:10.1080/08927014.2018.1462342.en_US
dc.description.abstractThe active moieties of the anti-biofilm natural compounds zosteric (ZA) and salicylic (SA) acids have been covalently immobilized on a low density polyethylene (LDPE) surface. The grafting procedure provided new non-toxic eco-friendly materials (LDPE-CA and LDPE-SA) with anti-biofilm properties superior to the conventional biocide-based approaches and with features suitable for applications in challenging fields where the use of antimicrobial agents is limited. Microbiological investigation proved that LDPE-CA and LDPE-SA: (1) reduced Escherichia coli biofilm biomass by up to 61% with a mechanism that did not affect bacterial viability; (2) significantly affected biofilm morphology, decreasing biofilm thickness, roughness, substratum coverage, cell and matrix polysaccharide bio-volumes by >80% and increasing the surface to bio-volume ratio; (3) made the biofilm more susceptible to ampicillin and ethanol. Since no molecules were leached from the surface, they remained constantly effective and below the lethal level; therefore, the risk of inducing resistance was minimized.en_US
dc.description.sponsorshipFondazione Cariplo (grant number 2011−0277)en_US
dc.rightsThis Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).en_US
dc.titleZosteric acid and salicylic acid bound to a low density polyethylene surface successfully control bacterial biofilm formationen_US
mus.identifier.categoryEngineering & Computer Scienceen_US
mus.relation.collegeCollege of Engineeringen_US
mus.relation.departmentChemical & Biological Engineering.en_US
mus.relation.universityMontana State University - Bozemanen_US

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