Show simple item record

dc.contributor.authorLachowiec, Jennifer A.
dc.contributor.authorMason, G. Alex
dc.contributor.authorSchultz, Karla
dc.contributor.authorQueitsch, Christine
dc.date.accessioned2019-01-11T17:58:21Z
dc.date.available2019-01-11T17:58:21Z
dc.date.issued2018-11
dc.identifier.citationLachowiec, Jennifer, G. Alex Mason, Karla Schultz, and Christine Queitsch. “Redundancy, Feedback, and Robustness in the Arabidopsis Thaliana BZR/BEH Gene Family.” Frontiers in Genetics 9 (November 13, 2018). doi:10.3389/fgene.2018.00523.en_US
dc.identifier.issn1664-8021
dc.identifier.urihttps://scholarworks.montana.edu/xmlui/handle/1/15122
dc.description.abstractOrganismal development is remarkably robust, tolerating stochastic errors to produce consistent, so-called canalized adult phenotypes. The mechanistic underpinnings of developmental robustness are poorly understood, but recent studies implicate certain features of genetic networks such as functional redundancy, connectivity, and feedback. Here, we examine the BZR/BEH gene family, whose function contributes to embryonic stem development in the plant Arabidopsis thaliana, to test current assumptions on functional redundancy and trait robustness. Our analyses of BZR/BEH gene mutants and mutant combinations revealed that functional redundancy among these gene family members is not necessary for trait robustness. Connectivity is another commonly cited determinant of robustness; however, we found no correlation between connectivity among gene family members or their connectivity with other transcription factors and effects on developmental robustness. Instead, our data suggest that BEH4, the earliest diverged family member, modulates developmental robustness. We present evidence indicating that regulatory cross-talk among gene family members is integrated by BEH4 to promote wild-type levels of developmental robustness. Further, the chaperone HSP90, a known determinant of developmental robustness, appears to act via BEH4 in maintaining robustness of embryonic stem length. In summary, we demonstrate that even among closely related transcription factors, trait robustness can arise through the activity of a single gene family member, challenging common assumptions about the molecular underpinnings of robustness.en_US
dc.description.sponsorshipNational Human Genome Research Institute; National Science Foundation DGE-0718124 & DGE–1256082; National Institutes of Health award no. DP2OD008371en_US
dc.language.isoenen_US
dc.rightsCC BY, This license lets you distribute, remix, tweak, and build upon this work, even commercially, as long as you credit the original creator for this work. This is the most accommodating of licenses offered. Recommended for maximum dissemination and use of licensed materials.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/legalcodeen_US
dc.titleRedundancy, Feedback, and Robustness in the Arabidopsis thaliana BZR/BEH Gene Familyen_US
dc.typeArticleen_US
mus.citation.journaltitleFrontiers in Geneticsen_US
mus.citation.volume9en_US
mus.identifier.categoryLife Sciences & Earth Sciencesen_US
mus.identifier.doi10.3389/fgene.2018.00523en_US
mus.relation.collegeCollege of Agricultureen_US
mus.relation.departmentPlant Sciences & Plant Pathology.en_US
mus.relation.universityMontana State University - Bozemanen_US
mus.data.thumbpage6en_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

CC BY, This license lets you distribute, remix, tweak, and build upon this work, even commercially, as long as you credit the original creator for this work. This is the most accommodating of licenses offered. Recommended for maximum dissemination and use of licensed materials.
Except where otherwise noted, this item's license is described as CC BY, This license lets you distribute, remix, tweak, and build upon this work, even commercially, as long as you credit the original creator for this work. This is the most accommodating of licenses offered. Recommended for maximum dissemination and use of licensed materials.

MSU uses DSpace software, copyright © 2002-2017  Duraspace. For library collections that are not accessible, we are committed to providing reasonable accommodations and timely access to users with disabilities. For assistance, please submit an accessibility request for library material.