NMR Relaxometry to Characterize the Drug Structural Phase in a Porous Construct
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2018-06
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Abstract
Nuclear magnetic resonance (NMR) frequency spectra and T2 relaxation time measurements, using a high-power radio frequency probe, are shown to characterize the presence of an amorphous drug in a porous silica construct. The results indicate the ability of non-solid-state NMR methods to characterize crystalline and amorphous solid structural phases in drugs. Two-dimensional T1–T2 magnetic relaxation time correlation experiments are shown to monitor the impact of relative humidity on the drug in a porous silica tablet.
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Thrane, Linn W., Emily A. Berglund, James N. Wilking, David Vodak, and Joseph D. Seymour, “NMR Relaxometry to Characterize the Drug Structural Phase in a Porous Construct,” Molecular Pharmaceutics, June 2018; 15(7): 2614-2620. doi: 10.1021/acs.molpharmaceut.8b00144