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dc.contributor.authorKaiser, Coleen R.
dc.contributor.authorFlenniken, Michelle L.
dc.contributor.authorGillitzer, Eric
dc.contributor.authorHarmsen, Ann L.
dc.contributor.authorHarmsen, Allen G.
dc.contributor.authorJutila, Mark A.
dc.contributor.authorDouglas, Trevor
dc.contributor.authorYoung, Mark J.
dc.date.accessioned2019-02-13T19:22:44Z
dc.date.available2019-02-13T19:22:44Z
dc.date.issued2007-12
dc.identifier.citationKaiser, Coleen R., Michelle L. Flenniken, Eric Gillitzer, Ann L. Harmsen, Allen G. Harmsen, Mark A. Jutila, Trevor Douglas, Mark J. Young (2007). Biodistribution studies of protein cage nanoparticles demonstrate broad tissue distribution and rapid clearance in vivo. International Journal of Nanomedicine, 2 (4), 713-733.en_US
dc.identifier.issn1178-2013
dc.identifier.urihttps://scholarworks.montana.edu/xmlui/handle/1/15262
dc.description.abstractProtein cage nanoparticles have the potential to serve as multifunctional cell targeted, imaging and therapeutic platforms for broad applications in medicine. However, before they find applications in medicine, their biocompatibility in vivo needs to be demonstrated. We provide here baseline biodistribution information of two different spherical protein cage nanoplatforms, the 28 nm viral Cowpea chlorotic mottle virus (CCMV) and the 12 nm heat shock protein (Hsp) cage. In naïve and immunized mice both nanoplatforms show similar broad distribution and movement throughout most tissues and organs, rapid excretion, the absence of long term persistence within mice tissue and organs, and no overt toxicity after a single injection. These results suggest that protein cage based nanoparticles may serve as safe, biocompatible, nanoplatforms for applications in medicine.en_US
dc.language.isoenen_US
dc.rightsCC BY: This license lets you distribute, remix, tweak, and build upon this work, even commercially, as long as you credit the original creator for this work. This is the most accommodating of licenses offered. Recommended for maximum dissemination and use of licensed materials.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/legalcodeen_US
dc.titleBiodistribution studies of protein cage nanoparticles demonstrate broad tissue distribution and rapid clearance in vivoen_US
dc.typeArticleen_US
mus.citation.extentfirstpage715en_US
mus.citation.extentlastpage733en_US
mus.citation.issue4en_US
mus.citation.journaltitleInternational Journal of Nanomedicineen_US
mus.citation.volume2en_US
mus.identifier.categoryLife Sciences & Earth Sciencesen_US
mus.relation.collegeCollege of Agricultureen_US
mus.relation.departmentPlant Sciences & Plant Pathology.en_US
mus.relation.universityMontana State University - Bozemanen_US
mus.data.thumbpage7en_US
mus.contributor.orcidFlenniken, Michelle L.|0000-0003-0356-3370en_US


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CC BY: This license lets you distribute, remix, tweak, and build upon this work, even commercially, as long as you credit the original creator for this work. This is the most accommodating of licenses offered. Recommended for maximum dissemination and use of licensed materials.
Except where otherwise noted, this item's license is described as CC BY: This license lets you distribute, remix, tweak, and build upon this work, even commercially, as long as you credit the original creator for this work. This is the most accommodating of licenses offered. Recommended for maximum dissemination and use of licensed materials.