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dc.contributor.advisorChairperson, Graduate Committee: Douglas Kominskyen
dc.contributor.authorSchneider, Stephanie Lorainen
dc.date.accessioned2019-03-27T14:07:01Z
dc.date.available2019-03-27T14:07:01Z
dc.date.issued2017en
dc.identifier.urihttps://scholarworks.montana.edu/xmlui/handle/1/15330
dc.description.abstractExtracellular ATP is a pro-inflammatory molecule released during intestinal insult and must be converted to adenosine by ecto-5'-nucleotidase (CD73) for the resolution of intestinal inflammation [1]. Along with its anti-inflammatory role in the intestinal mucosa, CD73-generated adenosine contributes to host-microbe interactions at the mucosal surface by modulating pathogen replication and virulence, including that of Salmonella enterica serovar Typhimurium (S. Typhimurium) [2], [3]. It has been shown, in the absence of intestinal epithelial cell-specific CD73, S. Typhimurium virulence is attenuated in vivo and in vitro, implicating the intestinal epithelium as an underappreciated source for the development of novel antimicrobial therapies. Since direct modulation of extracellular adenosine leads to pleiotropic effects, the aim of this research was to determine the mechanism(s) of S. Typhimurium virulence modulation by CD73 in intestinal epithelial cells to identify specific molecular targets that modulate pathogenesis [4], [5]en
dc.language.isoenen
dc.publisherMontana State University - Bozeman, College of Letters & Scienceen
dc.subject.lcshSalmonella.en
dc.subject.lcshInflammation.en
dc.subject.lcshNucleotides.en
dc.subject.lcshIntestines.en
dc.subject.lcshEpithelial cells.en
dc.titleValidating Salmonella typhimurium virulence modulation by ecto-5'-nucleotidase (CD73) in intestinal epithelial cellsen
dc.typeThesisen
dc.rights.holderCopyright 2017 by Stephanie Lorain Schneideren
thesis.degree.committeemembersMembers, Graduate Committee: Douglas Kominsky (chairperson); Jovanka Voyich-Kane; Edward E. Schmidt.en
thesis.degree.departmentMicrobiology & Immunology.en
thesis.degree.genreThesisen
thesis.degree.nameMSen
thesis.format.extentfirstpage1en
thesis.format.extentlastpage111en
mus.data.thumbpage87en


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