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dc.contributor.authorKing, Quinton O.
dc.contributor.authorLei, Benfang
dc.contributor.authorHarmsen, Allen G.
dc.identifier.citationKing, Quinton O., Benfang Lei, and Allen G. Harmsen. “Pneumococcal Surface Protein A Contributes to Secondary Streptococcus pneumoniaeInfection after Influenza Virus Infection.” The Journal of Infectious Diseases 200, no. 4 (August 15, 2009): 537–545. doi:10.1086/600871.en_US
dc.description.abstractWe compared the growth of Streptococcus pneumoniae mutants with a disruption in the gene for either pneumococcal surface protein A (PspA−), neuraminidase A (NanA−), or hyaluronidase (Hyl−) to that of the parental strain D39 by means of a competitive growth model in mice with and those without prior influenza virus infection. The numbers of total bacteria recovered from mice with prior influenza virus infection were significantly greater than those recovered from mice without prior influenza virus infection. Although the Hyl− and NanA− mutants did not display attenuation in mice with or without prior influenza virus infection, the PspA− mutant exhibited attenuation both in mice with and in mice without prior influenza virus infection. This defect was severe in influenza virus–infected mice, for which growth of the PspA− mutant was 1800-fold lower than that of the parental strain D39. Furthermore, PspA immunization significantly reduced secondary bacterial lung burdens and concentrations of specific markers of lung damage in mice receiving serotypes 2, 3, and 4 pneumococci. Our findings indicate that PspA contributes to secondary S. pneumoniae infection after influenza virus infection and that PspA immunization mitigates early secondary pneumococcal lung infections.en_US
dc.description.sponsorshipIDeA Network of Biomedical Research Excellence–Biomedical Research Infrastructure Network grant RR16455; National Institutes of Health Centers of Biomedical Research Excellence grant RR020185en_US
dc.rightsThis Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).en_US
dc.titlePneumococcal surface protein A contributes to secondary Streptococcus pneumoniae infection after influenza virus infectionen_US
mus.citation.journaltitleJournal of Infectious Diseasesen_US
mus.identifier.categoryLife Sciences & Earth Sciencesen_US
mus.relation.collegeCollege of Letters & Scienceen_US
mus.relation.departmentMicrobiology & Immunology.en_US
mus.relation.universityMontana State University - Bozemanen_US
mus.relation.researchgroupMT INBRE Bioinformatics and Biostatistics Core.en_US

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