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dc.contributor.authorRynda-Apple, Agnieszka
dc.contributor.authorDobrinen, Erin
dc.contributor.authorMcAlpine, Mark
dc.contributor.authorRead, Amanda
dc.contributor.authorHarmsen, Ann L.
dc.contributor.authorRichert, Laura E.
dc.contributor.authorCalverley, Matthew
dc.contributor.authorPallister, Kyler
dc.contributor.authorVoyich, Jovanka M.
dc.contributor.authorWiley, James A.
dc.contributor.authorJohnson, Ben
dc.contributor.authorYoung, Mark J.
dc.contributor.authorDouglas, Trevor
dc.contributor.authorHarmsen, Allen G.
dc.date.accessioned2019-04-22T19:34:00Z
dc.date.available2019-04-22T19:34:00Z
dc.date.issued2012-07
dc.identifier.citationRynda-Apple, Agnieszka, Erin Dobrinen, Mark McAlpine, Amanda Read, Ann L. Harmsen, Laura E. Richert, Matthew Calverley, Kyler Pallister, Jovanka M. Voyich, James A. Wiley, Ben Johnson, Mark J. Young, Trevor Douglas, Allen G. Harmsen. “Virus-Like Particle-Induced Protection Against MRSA Pneumonia Is Dependent on IL-13 and Enhancement of Phagocyte Function.” The American Journal of Pathology 181, no. 1 (July 2012): 196–210. doi:10.1016/j.ajpath.2012.03.018.en_US
dc.identifier.issn0002-9440
dc.identifier.urihttps://scholarworks.montana.edu/xmlui/handle/1/15455
dc.description.abstractThe importance of the priming of the lung environment by past infections is being increasingly recognized. Exposure to any given antigen can either improve or worsen the outcome of subsequent lung infections, depending on the immunological history of the host. Thus, an ability to impart transient alterations in the lung environment in anticipation of future insult could provide an important novel therapy for emerging infectious diseases. In this study, we show that nasal administration of virus-like particles (VLPs) before, or immediately after, lethal challenge with methicillin-resistant Staphylococcus aureus (MRSA) of mice i) ensures complete recovery from lung infection and near absolute clearance of bacteria within 12 hours of challenge, ii) reduces host response-induced lung tissue damage, iii) promotes recruitment and efficient bacterial clearance by neutrophils and CD11c+ cells, and iv) protects macrophages from MRSA-induced necrosis. VLP-mediated protection against MRSA relied on innate immunity. Complete recovery occurred in VLP-dosed mice with severe combined immunodeficiency, but not in wild-type mice depleted of either Ly6G+ or CD11c+ cells. Early IL-13 production associated with VLP-induced CD11c+ cells was essential for VLP-induced protection. These results indicate that VLP-induced alteration of the lung environment protects the host from lethal MRSA pneumonia by enhancing phagocyte recruitment and killing and by reducing inflammation-induced tissue damage via IL-13–dependent mechanisms.en_US
dc.description.sponsorshipNIH National Institute of Allergy and Infectious Diseases 1R56AI089458; NIH/IDeA Networks of Biomedical Research Excellence P20 RR16455, GM123456; NIH/Centers of Biomedical Research Excellence P20 RR020185, GM123456; NIH/Rocky Mountain Regional Center for Excellence U54 AI065357; M.J. Murdock Charitable Trust; Montana State University Agricultural Experimental Stationen_US
dc.language.isoenen_US
dc.rightsCC BY-NC-ND: This license is the most restrictive of our six main licenses, only allowing you to download this work and share it with others as long as you credit the original creator, but you can’t change the work in any way or use it commercially.en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/legalcodeen_US
dc.titleVirus-like Particle-Induced Protection against MRSA Pneumonia Is Dependent on IL-13 and Enhancement of Phagocyte Functionen_US
dc.typeArticleen_US
mus.citation.extentfirstpage196en_US
mus.citation.extentlastpage210en_US
mus.citation.issue1en_US
mus.citation.journaltitleAmerican Journal of Pathologyen_US
mus.citation.volume181en_US
mus.identifier.categoryLife Sciences & Earth Sciencesen_US
mus.identifier.doi10.1016/j.ajpath.2012.03.018en_US
mus.relation.collegeCollege of Agricultureen_US
mus.relation.collegeCollege of Letters & Scienceen_US
mus.relation.departmentChemistry & Biochemistry.en_US
mus.relation.departmentMicrobiology & Immunology.en_US
mus.relation.departmentPlant Sciences & Plant Pathology.en_US
mus.relation.universityMontana State University - Bozemanen_US
mus.relation.researchgroupMT INBRE Bioinformatics and Biostatistics Core.en_US
mus.data.thumbpage9en_US


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CC BY-NC-ND: This license is the most restrictive of our six main licenses, only allowing you to download this work and share it with others as long as you credit the original creator, but you can’t change the work in any way or use it commercially.
Except where otherwise noted, this item's license is described as CC BY-NC-ND: This license is the most restrictive of our six main licenses, only allowing you to download this work and share it with others as long as you credit the original creator, but you can’t change the work in any way or use it commercially.

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