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dc.contributor.authorRay, Lori
dc.contributor.authorIliff, Jeffrey J.
dc.contributor.authorHeys, Jeffrey J.
dc.date.accessioned2019-04-23T18:32:55Z
dc.date.available2019-04-23T18:32:55Z
dc.date.issued2019-03
dc.identifier.citationRay, Lori, Jeffrey J. Iliff, and Jeffrey J. Heys. "Analysis of convective and diffusive transport in the brain interstitium." Fluids and barriers of the CNS 16, no. 6 (March 2019). DOI:10.1186/s12987-019-0126-9.en_US
dc.identifier.issn2045-8118
dc.identifier.urihttps://scholarworks.montana.edu/xmlui/handle/1/15467
dc.description.abstractBackground Despite advances in in vivo imaging and experimental techniques, the nature of transport mechanisms in the brain remain elusive. Mathematical modelling verified using available experimental data offers a powerful tool for investigating hypotheses regarding extracellular transport of molecules in brain tissue. Here we describe a tool developed to aid in investigation of interstitial transport mechanisms, especially the potential for convection (or bulk flow) and its relevance to interstitial solute transport, for which there is conflicting evidence. Methods In this work, we compare a large body of published experimental data for transport in the brain to simulations of purely diffusive transport and simulations of combined convective and diffusive transport in the brain interstitium, incorporating current theories of perivascular influx and efflux. Results The simulations show (1) convective flow in the interstitium potentially of a similar magnitude to diffusive transport for molecules of interest and (2) exchange between the interstitium and perivascular space, whereby fluid and solutes may enter or exit the interstitium, are consistent with the experimental data. Simulations provide an upper limit for superficial convective velocity magnitude (approximately v = 50 μm min−1), a useful finding for researchers developing techniques to measure interstitial bulk flow. Conclusions For the large molecules of interest in neuropathology, bulk flow may be an important mechanism of interstitial transport. Further work is warranted to investigate the potential for bulk flow.en_US
dc.description.sponsorshipNSF (DMS-1361240)en_US
dc.language.isoenen_US
dc.rightsCC BY: This license lets you distribute, remix, tweak, and build upon this work, even commercially, as long as you credit the original creator for this work. This is the most accommodating of licenses offered. Recommended for maximum dissemination and use of licensed materials.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/legalcodeen_US
dc.titleAnalysis of convective and diffusive transport in the brain interstitiumen_US
dc.typeArticleen_US
mus.citation.issue6en_US
mus.citation.journaltitleFluids and barriers of the CNSen_US
mus.citation.volume16en_US
mus.identifier.categoryHealth & Medical Sciencesen_US
mus.identifier.doi10.1186/s12987-019-0126-9en_US
mus.relation.collegeCollege of Engineeringen_US
mus.relation.departmentChemical & Biological Engineering.en_US
mus.relation.universityMontana State University - Bozemanen_US
mus.data.thumbpage12en_US
mus.contributor.orcidRay, Lori|0000-0001-9083-7493en_US


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CC BY: This license lets you distribute, remix, tweak, and build upon this work, even commercially, as long as you credit the original creator for this work. This is the most accommodating of licenses offered. Recommended for maximum dissemination and use of licensed materials.
Except where otherwise noted, this item's license is described as CC BY: This license lets you distribute, remix, tweak, and build upon this work, even commercially, as long as you credit the original creator for this work. This is the most accommodating of licenses offered. Recommended for maximum dissemination and use of licensed materials.

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