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dc.contributor.authorWalsh, Danica J.
dc.contributor.authorLivinghouse, Tom
dc.contributor.authorGoeres, Darla M.
dc.contributor.authorMettler, Madelyn
dc.contributor.authorStewart, Philip S.
dc.date.accessioned2020-06-24T16:01:42Z
dc.date.available2020-06-24T16:01:42Z
dc.date.issued2019-10
dc.identifier.citationWalsh, Danica J., Tom Livinghouse, Darla M. Goeres, Madelyn Mettler, Philip S. Stewart, “Antimicrobial activity of naturally occurring phenols and derivatives against biofilm and planktonic bacteria,” Frontiers in Chemistry, October 2019, 7:653. doi: 10.3389/fchem.2019.00653en_US
dc.identifier.issn2296-2646
dc.identifier.urihttps://scholarworks.montana.edu/xmlui/handle/1/15956
dc.description.abstractBiofilm-forming bacteria present formidable challenges across diverse settings, and there is a need for new antimicrobial agents that are both environmentally acceptable and relatively potent against microorganisms in the biofilm state. The antimicrobial activity of three naturally occurring, low molecular weight, phenols, and their derivatives were evaluated against planktonic and biofilm Staphylococcus epidermidis and Pseudomonas aeruginosa. The structure activity relationships of eugenol, thymol, carvacrol, and their corresponding 2- and 4-allyl, 2-methallyl, and 2- and 4-n-propyl derivatives were evaluated. Allyl derivatives showed a consistent increased potency with both killing and inhibiting planktonic cells but they exhibited a decrease in potency against biofilms. This result underscores the importance of using biofilm assays to develop structure-activity relationships when the end target is biofilm.en_US
dc.language.isoen_USen_US
dc.rights© This manuscript version is made available under the CC-BY 4.0 licenseen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.titleAntimicrobial activity of naturally occurring phenols and derivatives against biofilm and planktonic bacteriaen_US
dc.typeArticleen_US
mus.citation.journaltitleFrontiers in Chemistryen_US
mus.identifier.doi10.3389/fchem.2019.00653en_US
mus.relation.collegeCollege of Engineeringen_US
mus.relation.collegeCollege of Letters & Scienceen_US
mus.relation.departmentCenter for Biofilm Engineering.en_US
mus.relation.departmentChemistry & Biochemistry.en_US
mus.relation.universityMontana State University - Bozemanen_US
mus.relation.researchgroupCenter for Biofilm Engineering.en_US
mus.data.thumbpage7en_US


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© This manuscript version is made available under the CC-BY 4.0 license
Except where otherwise noted, this item's license is described as © This manuscript version is made available under the CC-BY 4.0 license