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dc.contributor.authorBryant, Donald A.
dc.contributor.authorHunter, C. Neil
dc.contributor.authorWarren, Martin J.
dc.date.accessioned2021-09-13T16:01:41Z
dc.date.available2021-09-13T16:01:41Z
dc.date.issued2021-01
dc.identifier.citationBryant, Donald A., C. Neil Hunter, and Martin J. Warren. “Biosynthesis of the Modified Tetrapyrroles—the Pigments of Life.” Journal of Biological Chemistry 295, no. 20 (May 2020): 6888–6925. doi:10.1074/jbc.rev120.006194.en_US
dc.identifier.issn0021-9258
dc.identifier.urihttps://scholarworks.montana.edu/xmlui/handle/1/16439
dc.description.abstractModified tetrapyrroles are large macrocyclic compounds, consisting of diverse conjugation and metal chelation systems and imparting an array of colors to the biological structures that contain them. Tetrapyrroles represent some of the most complex small molecules synthesized by cells and are involved in many essential processes that are fundamental to life on Earth, including photosynthesis, respiration, and catalysis. These molecules are all derived from a common template through a series of enzyme-mediated transformations that alter the oxidation state of the macrocycle and also modify its size, its side-chain composition, and the nature of the centrally chelated metal ion. The different modified tetrapyrroles include chlorophylls, hemes, siroheme, corrins (including vitamin B12), coenzyme F430, heme d1, and bilins. After nearly a century of study, almost all of the more than 90 different enzymes that synthesize this family of compounds are now known, and expression of reconstructed operons in heterologous hosts has confirmed that most pathways are complete. Aside from the highly diverse nature of the chemical reactions catalyzed, an interesting aspect of comparative biochemistry is to see how different enzymes and even entire pathways have evolved to perform alternative chemical reactions to produce the same end products in the presence and absence of oxygen. Although there is still much to learn, our current understanding of tetrapyrrole biogenesis represents a remarkable biochemical milestone that is summarized in this review.en_US
dc.language.isoen_USen_US
dc.rights© This published version is made available under the CC-BY 4.0 license.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.titleBiosynthesis of the modified tetrapyrroles - the pigments of lifeen_US
dc.typeArticleen_US
mus.citation.extentfirstpage6888en_US
mus.citation.extentlastpage6925en_US
mus.citation.issue20en_US
mus.citation.journaltitleJournal of Biological Chemistryen_US
mus.citation.volume295en_US
mus.identifier.doi10.1074/jbc.rev120.006194en_US
mus.relation.collegeCollege of Letters & Scienceen_US
mus.relation.departmentChemistry & Biochemistry.en_US
mus.relation.universityMontana State University - Bozemanen_US
mus.data.thumbpage2en_US


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