Show simple item record

dc.contributor.authorBryant, Donald A.
dc.contributor.authorHunter, C. Neil
dc.contributor.authorWarren, Martin J.
dc.identifier.citationBryant, Donald A., C. Neil Hunter, and Martin J. Warren. “Biosynthesis of the Modified Tetrapyrroles—the Pigments of Life.” Journal of Biological Chemistry 295, no. 20 (May 2020): 6888–6925. doi:10.1074/jbc.rev120.006194.en_US
dc.description.abstractModified tetrapyrroles are large macrocyclic compounds, consisting of diverse conjugation and metal chelation systems and imparting an array of colors to the biological structures that contain them. Tetrapyrroles represent some of the most complex small molecules synthesized by cells and are involved in many essential processes that are fundamental to life on Earth, including photosynthesis, respiration, and catalysis. These molecules are all derived from a common template through a series of enzyme-mediated transformations that alter the oxidation state of the macrocycle and also modify its size, its side-chain composition, and the nature of the centrally chelated metal ion. The different modified tetrapyrroles include chlorophylls, hemes, siroheme, corrins (including vitamin B12), coenzyme F430, heme d1, and bilins. After nearly a century of study, almost all of the more than 90 different enzymes that synthesize this family of compounds are now known, and expression of reconstructed operons in heterologous hosts has confirmed that most pathways are complete. Aside from the highly diverse nature of the chemical reactions catalyzed, an interesting aspect of comparative biochemistry is to see how different enzymes and even entire pathways have evolved to perform alternative chemical reactions to produce the same end products in the presence and absence of oxygen. Although there is still much to learn, our current understanding of tetrapyrrole biogenesis represents a remarkable biochemical milestone that is summarized in this review.en_US
dc.rights© This published version is made available under the CC-BY 4.0 license.en_US
dc.titleBiosynthesis of the modified tetrapyrroles - the pigments of lifeen_US
mus.citation.journaltitleJournal of Biological Chemistryen_US
mus.relation.collegeCollege of Letters & Scienceen_US
mus.relation.departmentChemistry & Biochemistry.en_US
mus.relation.universityMontana State University - Bozemanen_US

Files in this item


This item appears in the following Collection(s)

Show simple item record

© This published version is made available under the CC-BY 4.0 license.
Except where otherwise noted, this item's license is described as © This published version is made available under the CC-BY 4.0 license.

MSU uses DSpace software, copyright © 2002-2017  Duraspace. For library collections that are not accessible, we are committed to providing reasonable accommodations and timely access to users with disabilities. For assistance, please submit an accessibility request for library material.