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dc.contributor.authorKudryavtseva, Valeriya
dc.contributor.authorStankevich, Ksenia
dc.contributor.authorKozelskaya, Anna
dc.contributor.authorKibler, Elina
dc.contributor.authorZhukov, Yuri
dc.contributor.authorMalashicheva, Anna
dc.contributor.authorGolovkin, Alexey
dc.contributor.authorMishanin, Alexander
dc.contributor.authorFilimonov, Victor
dc.contributor.authorBolbasov, Evgeny
dc.contributor.authorTverdokhlebov, Sergei
dc.identifier.citationKudryavtseva, Valeriya, Ksenia Stankevich, Anna Kozelskaya, Elina Kibler, Yuri Zhukov, Anna Malashicheva, Alexey Golovkin, et al. “Magnetron Plasma Mediated Immobilization of Hyaluronic Acid for the Development of Functional Double-Sided Biodegradable Vascular Graft.” Applied Surface Science 529 (November 2020): 147196. doi:10.1016/j.apsusc.2020.147196.en_US
dc.description.abstractThe clinical need for vascular grafts is associated with cardiovascular diseases frequently leading to fatal outcomes. Artificial vessels based on bioresorbable polymers can replace the damaged vascular tissue or create a bypass path for blood flow while stimulating regeneration of a blood vessel in situ. However, the problem of proper conditions for the cells to grow on the vascular graft from the adventitia while maintaining its mechanical integrity of the luminal surface remains a challenge. In this work, we propose a two-stage technology for processing electrospun vascular graft from polycaprolactone, which consists of plasma treatment and subsequent immobilization of hyaluronic acid on its surface producing thin double-sided graft with one hydrophilic and one hydrophobic side. Plasma modification activates the polymer surfaces and produces a thin layer for linker-free immobilisation of bioactive molecules, thereby producing materials with unique properties. Proposed modification does not affect the morphology or mechanical properties of the graft and improves cell adhesion. The proposed approach can potentially be used for various biodegradable polymers such as polylactic acid, polyglycolide and their copolymers and blends, with a hydrophilic inner surface and a hydrophobic outer surface.en_US
dc.rights© This manuscript version is made available under the CC-BY-NC-ND 4.0 license.en_US
dc.titleMagnetron plasma mediated immobilization of hyaluronic acid for the development of functional double-sided biodegradable vascular graften_US
mus.citation.journaltitleApplied Surface Scienceen_US
mus.relation.collegeCollege of Letters & Scienceen_US
mus.relation.departmentChemistry & Biochemistry.en_US
mus.relation.universityMontana State University - Bozemanen_US

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