Show simple item record

dc.contributor.authorWalsh, Danica J.
dc.contributor.authorLivinghouse, Tom
dc.contributor.authorDurling, Greg M.
dc.contributor.authorArnold, Adrienne D.
dc.contributor.authorBrasier, Whitney
dc.contributor.authorBerry, Luke
dc.contributor.authorGoeres, Darla M.
dc.contributor.authorStewart, Philip S.
dc.identifier.citationWalsh, D. J., Livinghouse, T., Durling, G. M., Arnold, A. D., Brasier, W., Berry, L., ... & Stewart, P. S. (2021). Novel phenolic antimicrobials enhanced activity of iminodiacetate prodrugs against biofilm and planktonic bacteria. Chemical biology & drug design, 97(1), 134-147.en_US
dc.description.abstractProdrugs are pharmacologically attenuated derivatives of drugs that undergo bioconversion into the active compound once reaching the targeted site, thereby maximizing their efficiency. This strategy has been implemented in pharmaceuticals to overcome obstacles related to absorption, distribution, and metabolism, as well as with intracellular dyes to ensure concentration within cells. In this study, we provide the first examples of a prodrug strategy that can be applied to simple phenolic antimicrobials to increase their potency against mature biofilms. The addition of (acetoxy)methyl iminodiacetate groups increases the otherwise modest potency of simple phenols. Biofilm-forming bacteria exhibit a heightened tolerance toward antimicrobial agents, thereby accentuating the need for new antibiotics as well as those, which incorporate novel delivery strategies to enhance activity toward biofilms.en_US
dc.titleNovel phenolic antimicrobials enhanced activity of iminodiacetate prodrugs against biofilm and planktonic bacteriaen_US
mus.citation.journaltitleChemical Biology & Drug Designen_US
mus.relation.collegeCollege of Engineeringen_US
mus.relation.departmentCenter for Biofilm Engineering.en_US
mus.relation.departmentChemical & Biological Engineering.en_US
mus.relation.departmentMicrobiology & Cell Biology.en_US
mus.relation.universityMontana State University - Bozemanen_US

Files in this item


This item appears in the following Collection(s)

Show simple item record
Except where otherwise noted, this item's license is described as

MSU uses DSpace software, copyright © 2002-2017  Duraspace. For library collections that are not accessible, we are committed to providing reasonable accommodations and timely access to users with disabilities. For assistance, please submit an accessibility request for library material.