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dc.contributor.authorMcGill, S. Lee
dc.contributor.authorYung, Yeni
dc.contributor.authorHunt, Kristopher A.
dc.contributor.authorHenson, Michael A.
dc.contributor.authorHanley, Luke
dc.contributor.authorCarlson, Ross P.
dc.identifier.citationMcGill, S. L., Yung, Y., Hunt, K. A., Henson, M. A., Hanley, L., & Carlson, R. P. (2021). Pseudomonas aeruginosa reverse diauxie is a multidimensional, optimized, resource utilization strategy. Scientific reports, 11(1), 1-16.en_US
dc.description.abstractPseudomonas aeruginosa is a globally-distributed bacterium often found in medical infections. The opportunistic pathogen uses a different, carbon catabolite repression (CCR) strategy than many, model microorganisms. It does not utilize a classic diauxie phenotype, nor does it follow common systems biology assumptions including preferential consumption of glucose with an ‘overflow’ metabolism. Despite these contradictions, P. aeruginosa is competitive in many, disparate environments underscoring knowledge gaps in microbial ecology and systems biology. Physiological, omics, and in silico analyses were used to quantify the P. aeruginosa CCR strategy known as ‘reverse diauxie’. An ecological basis of reverse diauxie was identified using a genome-scale, metabolic model interrogated with in vitro omics data. Reverse diauxie preference for lower energy, nonfermentable carbon sources, such as acetate or succinate over glucose, was predicted using a multidimensional strategy which minimized resource investment into central metabolism while completely oxidizing substrates. Application of a common, in silico optimization criterion, which maximizes growth rate, did not predict the reverse diauxie phenotypes. This study quantifies P. aeruginosa metabolic strategies foundational to its wide distribution and virulence including its potentially, mutualistic interactions with microorganisms found commonly in the environment and in medical infections.en_US
dc.publisherSpringer Science and Business Media LLCen_US
dc.titlePseudomonas aeruginosa reverse diauxie is a multidimensional, optimized, resource utilization strategyen_US
mus.citation.journaltitleScientific Reportsen_US
mus.relation.collegeCollege of Engineeringen_US
mus.relation.departmentCenter for Biofilm Engineering.en_US
mus.relation.departmentChemical & Biological Engineering.en_US
mus.relation.departmentMicrobiology & Cell Biology.en_US
mus.relation.universityMontana State University - Bozemanen_US
mus.relation.researchgroupCenter for Biofilm Engineering.en_US

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