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dc.contributor.authorHatzenpichler, Roland
dc.contributor.authorKrukenberg, Viola
dc.contributor.authorSpietz, Rachel L.
dc.contributor.authorJay, Zackary J.
dc.identifier.citationHatzenpichler, R., Krukenberg, V., Spietz, R. L., & Jay, Z. J. (2020). Next-generation physiology approaches to study microbiome function at single cell level. Nature Reviews Microbiology, 18(4), 241-256.en_US
dc.description.abstractThe function of cells in their native habitat often cannot be reliably predicted from genomic data or from physiology studies of isolates. Traditional experimental approaches to study the function of taxonomically and metabolically diverse microbiomes are limited by their destructive nature, low spatial resolution or low throughput. Recently developed technologies can offer new insights into cellular function in natural and human-made systems and how microorganisms interact with and shape the environments that they inhabit. In this Review, we provide an overview of these next-generation physiology approaches and discuss how the non-destructive analysis of cellular phenotypes, in combination with the separation of the target cells for downstream analyses, provide powerful new, complementary ways to study microbiome function. We anticipate that the widespread application of next-generation physiology approaches will transform the field of microbial ecology and dramatically improve our understanding of how microorganisms function in their native environment.en_US
dc.publisherSpringer Science and Business Media LLCen_US
dc.titleNext-generation physiology approaches to study microbiome function at single cell levelen_US
mus.relation.collegeCollege of Engineeringen_US
mus.relation.departmentCenter for Biofilm Engineering.en_US
mus.relation.departmentChemistry & Biochemistry.en_US
mus.relation.universityMontana State University - Bozemanen_US
mus.relation.researchgroupCenter for Biofilm Engineering.en_US
mus.relation.researchgroupThermal Biology Institute (TBI).en_US

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