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dc.contributor.authorTverdokhlebova, Tamara S.
dc.contributor.authorAntipina, Ludmila S.
dc.contributor.authorKudryavtseva, Valeriya L.
dc.contributor.authorStankevich, Ksenia S.
dc.contributor.authorKolesnik, Ilya M.
dc.contributor.authorSenokosova, Evgenia A.
dc.contributor.authorVelikanova, Elena A.
dc.contributor.authorAntonova, Larisa V.
dc.contributor.authorVasilchenko, Dmitry V.
dc.contributor.authorDambaev, Georgiy T.
dc.contributor.authorPlotnikov, Evgenii V.
dc.contributor.authorBouznik, Vyacheslav M.
dc.contributor.authorBolbasov, Evgeny N.
dc.date.accessioned2022-08-04T21:40:52Z
dc.date.available2022-08-04T21:40:52Z
dc.date.issued2020-12
dc.identifier.citationTverdokhlebova, T.S.; Antipina, L.S.; Kudryavtseva, V.L.; Stankevich, K.S.; Kolesnik, I.M.; Senokosova, E.A.; Velikanova, E.A.; Antonova, L.V.; Vasilchenko, D.V.; Dambaev, G.T.; et al. Composite Ferroelectric Membranes Based on Vinylidene Fluoride- Tetrafluoroethylene Copolymer and Polyvinylpyrrolidone forWound Healing. Membranes 2021, 11, 21. https://doi.org/10.3390/ membranes11010021en_US
dc.identifier.issn2077-0375
dc.identifier.urihttps://scholarworks.montana.edu/xmlui/handle/1/16995
dc.description.abstractWound healing is a complex process and an ongoing challenge for modern medicine. Herein, we present the results of study of structure and properties of ferroelectric composite polymer membranes for wound healing. Membranes were fabricated by electrospinning from a solution of vinylidene fluoride/tetrafluoroethylene copolymer (VDF–TeFE) and polyvinylpyrrolidone (PVP) in dimethylformamide (DMF). The effects of the PVP content on the viscosity and conductivity of the spinning solution, DMF concentration, chemical composition, crystal structure, and conformation of VDF–TeFE macromolecules in the fabricated materials were studied. It was found that as PVP amount increased, the viscosity and conductivity of the spinning solutions decreased, resulting in thinner fibers. Using FTIR and XRD methods, it was shown that if the PVP content was lower than 50 wt %, the VDF–TeFE copolymer adopted a flat zigzag conformation (TTT conformation) and crystalline phases with ferroelectric properties were formed. Gas chromatography results indicated that an increase in the PVP concentration led to a higher residual amount of DMF in the material, causing cytotoxic effects on 3T3L1 fibroblasts. In vivo studies demonstrated that compared to classical gauze dressings impregnated with a solution of an antibacterial agent, ferroelectric composite membranes with 15 wt % PVP provided better conditions for the healing of purulent wounds.en_US
dc.language.isoen_USen_US
dc.publisherMDPI AGen_US
dc.rightsCC BY 4.0en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.titleComposite Ferroelectric Membranes Based on Vinylidene Fluoride-Tetrafluoroethylene Copolymer and Polyvinylpyrrolidone for Wound Healingen_US
dc.typeArticleen_US
mus.citation.extentfirstpage21en_US
mus.citation.issue1en_US
mus.citation.journaltitleMembranesen_US
mus.citation.volume11en_US
mus.identifier.doi10.3390/ membranes11010021en_US
mus.relation.collegeCollege of Letters & Scienceen_US
mus.relation.departmentChemistry & Biochemistry.en_US
mus.relation.universityMontana State University - Bozemanen_US
mus.data.thumbpage1en_US


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