Structure guided generation of thieno[3,2-d]pyrimidin-4-amine Mycobacterium tuberculosis bd oxidase inhibitors
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Date
2021-01Author
Hopfner, Sarah M.
Lee, Bei Shi
Kalia, Nitin P.
Miller, Marvin J.
Pethe, Kevin
Moraski, Garrett C.
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Screening for inhibitors of Cyt-bd in Mycobacterium bovis BCG and Mycobacterium tuberculosis revealed thieno[3,2-d]pyrimidine (7) which through SAR efforts resulted in an improved analogue (19) of this scaffold.
Citation
Hopfner, S. M., Lee, B. S., Kalia, N. P., Miller, M. J., Pethe, K., & Moraski, G. C. (2021). Structure guided generation of thieno [3, 2-d] pyrimidin-4-amine Mycobacterium tuberculosis bd oxidase inhibitors. RSC medicinal chemistry, 12(1), 73-77.