Molecular Mechanisms for Regulation of Neutrophil Apoptosis under Normal and Pathological Conditions
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Date
2021-05
Journal Title
Journal ISSN
Volume Title
Publisher
Pleiades Publishing Ltd
Abstract
Neutrophils are one of the main cells of innate immunity that perform a key effector and regulatory function in the development of the human inflammatory response. Apoptotic forms of neutrophils are important for regulating the intensity of inflammation and restoring tissue homeostasis. This review summarizes current data on the molecular mechanisms of modulation of neutrophil apoptosis by the main regulatory factors of the inflammatory response—cytokines, integrins, and structural components of bacteria. Disturbances in neutrophil apoptosis under stress are also considered, molecular markers of changes in neutrophil lifespan associated with various diseases and pathological conditions are presented, and data on pharmacological agents for modulating apoptosis as potential therapeutics are also discussed.
Description
Keywords
neutrophils, apoptosis, inflammation, stress, innate immunity, cytokines, cell life span
Citation
Noseykina, E. M., Schepetkin, I. A., & Atochin, D. N. (2021). Molecular mechanisms for regulation of neutrophil apoptosis under normal and pathological conditions. Journal of Evolutionary Biochemistry and Physiology, 57(3), 429-450.