Show simple item record

dc.contributor.authorWilson, Stephanie M.
dc.contributor.authorMaes, Adam P.
dc.contributor.authorYeoman, Carl J.
dc.contributor.authorWalk, Seth T.
dc.contributor.authorMiles, Mary P.
dc.date.accessioned2022-12-29T17:18:17Z
dc.date.available2022-12-29T17:18:17Z
dc.date.issued2021-09
dc.identifier.citationWilson, S. M., Maes, A. P., Yeoman, C. J., Walk, S. T., & Miles, M. P. (2021). Determinants of the postprandial triglyceride response to a high-fat meal in healthy overweight and obese adults. Lipids in health and disease, 20(1), 1-11.en_US
dc.identifier.issn1476-511X
dc.identifier.urihttps://scholarworks.montana.edu/xmlui/handle/1/17546
dc.description.abstractBackground. Dyslipidemia is a feature of impaired metabolic health in conjunction with impaired glucose metabolism and central obesity. However, the contribution of factors to postprandial lipemia in healthy but metabolically at-risk adults is not well understood. We investigated the collective contribution of several physiologic and lifestyle factors to postprandial triglyceride (TG) response to a high-fat meal in healthy, overweight and obese adults. Methods. Overweight and obese adults (n = 35) underwent a high-fat meal challenge with blood sampled at fasting and hourly in the 4-hour postprandial period after a breakfast containing 50 g fat. Incremental area under the curve (iAUC) and postprandial magnitude for TG were calculated and data analyzed using a linear model with physiologic and lifestyle characteristics as explanatory variables. Model reduction was used to assess which explanatory variables contributed most to the postprandial TG response. Results. TG responses to a high-fat meal were variable between individuals, with approximately 57 % of participants exceeded the nonfasting threshold for hypertriglyceridemia. Visceral adiposity was the strongest predictor of TG iAUC (β = 0.53, p = 0.01), followed by aerobic exercise frequency (β = 0.31, p = 0.05), insulin resistance based on HOMA-IR (β = 0.30, p = 0.04), and relative exercise intensity at which substrate utilization crossover occurred (β = 0.05, p = 0.04). For postprandial TG magnitude, visceral adiposity was a strong predictor (β = 0.43, p < 0.001) followed by aerobic exercise frequency (β = 0.23, p = 0.01), and exercise intensity for substrate utilization crossover (β = 0.53, p = 0.01). Conclusions. Postprandial TG responses to a high-fat meal was partially explained by several physiologic and lifestyle characteristics, including visceral adiposity, insulin resistance, aerobic exercise frequency, and relative substrate utilization crossover during exercise.en_US
dc.language.isoen_USen_US
dc.publisherSpringer Natureen_US
dc.rightscc-byen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.subjectPostprandial lipemiaen_US
dc.subjectHigh-fat mealen_US
dc.subjectObesityen_US
dc.subjectmetabolic syndromeen_US
dc.titleDeterminants of the postprandial triglyceride response to a high-fat meal in healthy overweight and obese adultsen_US
dc.typeArticleen_US
mus.citation.extentfirstpage1en_US
mus.citation.extentlastpage11en_US
mus.citation.journaltitleLipids in Health and Diseaseen_US
mus.citation.volume20en_US
mus.identifier.doi10.1186/s12944-021-01543-4en_US
mus.relation.collegeCollege of Education, Health & Human Developmenten_US
mus.relation.departmentHealth & Human Development.en_US
mus.relation.universityMontana State University - Bozemanen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

cc-by
Except where otherwise noted, this item's license is described as cc-by

MSU uses DSpace software, copyright © 2002-2017  Duraspace. For library collections that are not accessible, we are committed to providing reasonable accommodations and timely access to users with disabilities. For assistance, please submit an accessibility request for library material.