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dc.contributor.authorWilson, Stephanie M.
dc.contributor.authorMaes, Adam P.
dc.contributor.authorYeoman, Carl J.
dc.contributor.authorWalk, Seth T.
dc.contributor.authorMiles, Mary P.
dc.identifier.citationWilson, S. M., Maes, A. P., Yeoman, C. J., Walk, S. T., & Miles, M. P. (2021). Determinants of the postprandial triglyceride response to a high-fat meal in healthy overweight and obese adults. Lipids in health and disease, 20(1), 1-11.en_US
dc.description.abstractBackground. Dyslipidemia is a feature of impaired metabolic health in conjunction with impaired glucose metabolism and central obesity. However, the contribution of factors to postprandial lipemia in healthy but metabolically at-risk adults is not well understood. We investigated the collective contribution of several physiologic and lifestyle factors to postprandial triglyceride (TG) response to a high-fat meal in healthy, overweight and obese adults. Methods. Overweight and obese adults (n = 35) underwent a high-fat meal challenge with blood sampled at fasting and hourly in the 4-hour postprandial period after a breakfast containing 50 g fat. Incremental area under the curve (iAUC) and postprandial magnitude for TG were calculated and data analyzed using a linear model with physiologic and lifestyle characteristics as explanatory variables. Model reduction was used to assess which explanatory variables contributed most to the postprandial TG response. Results. TG responses to a high-fat meal were variable between individuals, with approximately 57 % of participants exceeded the nonfasting threshold for hypertriglyceridemia. Visceral adiposity was the strongest predictor of TG iAUC (β = 0.53, p = 0.01), followed by aerobic exercise frequency (β = 0.31, p = 0.05), insulin resistance based on HOMA-IR (β = 0.30, p = 0.04), and relative exercise intensity at which substrate utilization crossover occurred (β = 0.05, p = 0.04). For postprandial TG magnitude, visceral adiposity was a strong predictor (β = 0.43, p < 0.001) followed by aerobic exercise frequency (β = 0.23, p = 0.01), and exercise intensity for substrate utilization crossover (β = 0.53, p = 0.01). Conclusions. Postprandial TG responses to a high-fat meal was partially explained by several physiologic and lifestyle characteristics, including visceral adiposity, insulin resistance, aerobic exercise frequency, and relative substrate utilization crossover during exercise.en_US
dc.publisherSpringer Natureen_US
dc.subjectPostprandial lipemiaen_US
dc.subjectHigh-fat mealen_US
dc.subjectmetabolic syndromeen_US
dc.titleDeterminants of the postprandial triglyceride response to a high-fat meal in healthy overweight and obese adultsen_US
mus.citation.journaltitleLipids in Health and Diseaseen_US
mus.relation.collegeCollege of Education, Health & Human Developmenten_US
mus.relation.departmentHealth & Human Development.en_US
mus.relation.universityMontana State University - Bozemanen_US

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