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dc.contributor.authorRay, Lori A.
dc.contributor.authorPike, Martin
dc.contributor.authorSimon, Matthew
dc.contributor.authorIliff, Jeffrey J.
dc.contributor.authorHeys, Jeffrey J.
dc.date.accessioned2022-12-30T16:48:14Z
dc.date.available2022-12-30T16:48:14Z
dc.date.issued2021-12
dc.identifier.citationRay, L.A., Pike, M., Simon, M. et al. Quantitative analysis of macroscopic solute transport in the murine brain. Fluids Barriers CNS 18, 55 (2021). https://doi.org/10.1186/s12987-021-00290-zen_US
dc.identifier.issn2045-8118
dc.identifier.urihttps://scholarworks.montana.edu/xmlui/handle/1/17553
dc.description.abstractBackground. Understanding molecular transport in the brain is critical to care and prevention of neurological disease and injury. A key question is whether transport occurs primarily by diffusion, or also by convection or dispersion. Dynamic contrast-enhanced (DCE-MRI) experiments have long reported solute transport in the brain that appears to be faster than diffusion alone, but this transport rate has not been quantified to a physically relevant value that can be compared to known diffusive rates of tracers. Methods. In this work, DCE-MRI experimental data is analyzed using subject-specific finite-element models to quantify transport in different anatomical regions across the whole mouse brain. The set of regional effective diffusivities (Deff), a transport parameter combining all mechanisms of transport, that best represent the experimental data are determined and compared to apparent diffusivity (Dapp), the known rate of diffusion through brain tissue, to draw conclusions about dominant transport mechanisms in each region. Results. In the perivascular regions of major arteries, Deff for gadoteridol (550 Da) was over 10,000 times greater than Dapp. In the brain tissue, constituting interstitial space and the perivascular space of smaller blood vessels, Deff was 10–25 times greater than Dapp. Conclusions. The analysis concludes that convection is present throughout the brain. Convection is dominant in the perivascular space of major surface and branching arteries (Pe > 1000) and significant to large molecules (> 1 kDa) in the combined interstitial space and perivascular space of smaller vessels (not resolved by DCE-MRI). Importantly, this work supports perivascular convection along penetrating blood vessels.en_US
dc.language.isoen_USen_US
dc.publisherSpringer Natureen_US
dc.rightscc-byen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.subjectBiotransporten_US
dc.subjectBrain transporten_US
dc.subjectGlymphaticen_US
dc.subjectPerivascular transporten_US
dc.subjectInterstitial transporten_US
dc.subjectDynamic contrast-enhanced MRIen_US
dc.titleQuantitative analysis of macroscopic solute transport in the murine brainen_US
dc.typeArticleen_US
mus.citation.extentfirstpage1en_US
mus.citation.extentlastpage19en_US
mus.citation.volume18en_US
mus.identifier.doi10.1186/s12987-021-00290-zen_US
mus.relation.collegeCollege of Engineeringen_US
mus.relation.departmentChemical & Biological Engineering.en_US
mus.relation.universityMontana State University - Bozemanen_US


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