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dc.contributor.authorRegulski, Matthew
dc.contributor.authorMyntti, Matthew F.
dc.contributor.authorJames, Garth A.
dc.date.accessioned2023-05-24T19:44:44Z
dc.date.available2023-05-24T19:44:44Z
dc.date.issued2023-03
dc.identifier.citationRegulski M, Myntti MF, James GA. Anti-Biofilm Efficacy of Commonly Used Wound Care Products in In Vitro Settings. Antibiotics. 2023; 12(3):536. https://doi.org/10.3390/antibiotics12030536en_US
dc.identifier.issn2079-6382
dc.identifier.urihttps://scholarworks.montana.edu/xmlui/handle/1/17904
dc.description.abstractConsidering the prevalence and pathogenicity of biofilms in wounds, this study was designed to evaluate the anti-biofilm capabilities of eight commercially available wound care products using established in vitro assays for biofilms. The products evaluated included dressings with multiple delivery formats for ionic silver including nanocrystalline, gelling fibers, polyurethane (PU) foam, and polymer matrix. Additionally, non-silver-based products including an extracellular polymeric substance (EPS)-dissolving antimicrobial wound gel (BDWG), a collagenase-based debriding ointment and a fish skin-based skin substitute were also evaluated. The products were evaluated on Staphylococcus aureus and Pseudomonas aeruginosa mixed-species biofilms grown using colony drip flow reactor (CDFR) and standard drip flow reactor (DFR) methodologies. Anti-biofilm efficacy was measured by viable plate counts and confocal scanning laser microscopy (CSLM). Four of the eight wound care products tested were efficacious in inhibiting growth of new biofilm when compared with untreated controls. These four products were further evaluated against mature biofilms. BDWG was the only product that achieved greater than 2-log growth reduction (5.88 and 6.58 for S. aureus and P. aeruginosa, respectively) of a mature biofilm. Evaluating both biofilm prevention and mature biofilm disruption capacity is important to a comprehensive understanding of the anti-biofilm efficacy of wound care products.en_US
dc.language.isoen_USen_US
dc.publisherMDPI AGen_US
dc.rightscc-byen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.subjectbiofilmen_US
dc.subjectbiofilm disruptionen_US
dc.subjectound gelen_US
dc.subjectsilver dressingsen_US
dc.subjectcollagenaseen_US
dc.subjectchronic woundsen_US
dc.subjectwound infectionen_US
dc.subjectin vitro biofiom modelsen_US
dc.titleAnti-Biofilm Efficacy of Commonly Used Wound Care Products in In Vitro Settingsen_US
dc.typeArticleen_US
mus.citation.extentfirstpage1en_US
mus.citation.extentlastpage15en_US
mus.citation.issue3en_US
mus.citation.journaltitleAntibioticsen_US
mus.citation.volume12en_US
mus.identifier.doi10.3390/antibiotics12030536en_US
mus.relation.collegeCollege of Engineeringen_US
mus.relation.departmentCenter for Biofilm Engineering.en_US
mus.relation.universityMontana State University - Bozemanen_US
mus.data.thumbpage5en_US


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