Leukocyte Adhesion Molecule Expression During Intense Resistance Exercise
Date
1998Author
Miles, Mary
Leach, S.K.
Kraemer, W.J.
Dohi, K.
Bush, J.A.
Mastro, A.M.
Metadata
Show full item recordAbstract
We hypothesized that expression of L-selectin and very late
antigen-4 (VLA-4) integrin adhesion molecules would influence
cell type-specific redistribution during exercise. Women
subjects performed six sets of 10-repetition maximum squats.
L-selectin and VLA-4 integrin were measured by using flow
cytometry pre- and postexercise on peripheral blood neutrophils
and lymphocytes (n 5 29 subjects) and lymphocyte
subsets (n 5 70 subjects), respectively. Neutrophil concentration
increased 41.8% (P , 0.001), whereas the percent
expressing L-selectin was unchanged (79%). Lymphocyte
concentration increased 61.8% (P , 0.001). The percent of T
cells expressing L-selectin decreased from 73.5 6 8.9 to
68.2 6 11.4% (P , 0.001); the combined population of natural
killer and B cells expressing L-selectin decreased from 80.4 6
22.5 to 62.7 6 25.8% (P , 0.001). VLA-4 integrin was
expressed by nearly all lymphocytes both pre- and postexercise.
The proportional decrease in L-selectin positive cells
could have resulted from 1) shedding of L-selectin, 2) selective
entry of L-selectin-negative subsets, or 3) selective
removal of L-selectin-positive subsets.
Citation
Miles MP, SK Leach, WJ Kraemer, K Dohi, JA Bush, and AM Mastro. Leukocyte adhesion molecule expression during intense resistance exercise. Journal of Applied Physiology 84(5):1604-9, 1998.