Leukocyte Adhesion Molecule Expression During Intense Resistance Exercise
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Date
1998
Journal Title
Journal ISSN
Volume Title
Publisher
American Physiological Society
Abstract
We hypothesized that expression of L-selectin and very late
antigen-4 (VLA-4) integrin adhesion molecules would influence
cell type-specific redistribution during exercise. Women
subjects performed six sets of 10-repetition maximum squats.
L-selectin and VLA-4 integrin were measured by using flow
cytometry pre- and postexercise on peripheral blood neutrophils
and lymphocytes (n 5 29 subjects) and lymphocyte
subsets (n 5 70 subjects), respectively. Neutrophil concentration
increased 41.8% (P , 0.001), whereas the percent
expressing L-selectin was unchanged (79%). Lymphocyte
concentration increased 61.8% (P , 0.001). The percent of T
cells expressing L-selectin decreased from 73.5 6 8.9 to
68.2 6 11.4% (P , 0.001); the combined population of natural
killer and B cells expressing L-selectin decreased from 80.4 6
22.5 to 62.7 6 25.8% (P , 0.001). VLA-4 integrin was
expressed by nearly all lymphocytes both pre- and postexercise.
The proportional decrease in L-selectin positive cells
could have resulted from 1) shedding of L-selectin, 2) selective
entry of L-selectin-negative subsets, or 3) selective
removal of L-selectin-positive subsets.
Description
Keywords
Health sciences, Immunology
Citation
Miles MP, SK Leach, WJ Kraemer, K Dohi, JA Bush, and AM Mastro. Leukocyte adhesion molecule expression during intense resistance exercise. Journal of Applied Physiology 84(5):1604-9, 1998.