Scholarly Work - Microbiology & Immunology
Recent Submissions
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Case series: rheumatological manifestations attributed to exposure to Libby Asbestiform Amphiboles
(2018-06)An increased risk for Systemic Autoimmune Diseases (SAID) has been reported in Libby, Montana, where extensive exposures to fibrous amphiboles occurred due to mining and use of asbestos-laden vermiculite. In addition, ... -
A bioinformatic pipeline for identifying informative SNP panels for parentage assignment from RADseq data
(2018-06)The development of high-throughput sequencing technologies is dramatically increasing the use of single nucleotide polymorphisms (SNPs) across the field of genetics, but most parentage studies of wild populations still ... -
Origin and Evolution of Flavin-Based Electron Bifurcating Enzymes
(2018-08)Twelve evolutionarily unrelated oxidoreductases form enzyme complexes that catalyze the simultaneous coupling of exergonic and endergonic oxidation-reduction reactions to circumvent thermodynamic barriers and minimize free ... -
Health Effects from Exposure to Atmospheric Mineral Dust Near Las Vegas, NV, USA
(2016-09)Desert areas are usually characterized by a continuous deposition of fine airborne particles. Over time, this process results in the accumulation of silt and clay on desert surfaces. We evaluated health effects associated ... -
Structure reveals mechanisms of viral suppressors that intercept a CRISPR RNA-guided surveillance complex
(2017-03)Genetic conflict between viruses and their hosts drives evolution and genetic innovation. Prokaryotes evolved CRISPR-mediated adaptive immune systems for protection from viral infection, and viruses have evolved diverse ... -
The path of electron transfer to nitrogenase in a phototrophic alpha-proteobacterium
(2018-07)The phototrophic alpha-proteobacterium, Rhodopseudomonas palustris, is a model for studies of regulatory and physiological parameters that control the activity of nitrogenase. This enzyme produces the energy-rich compound ... -
IFNAR2 Is Required for Anti-influenza Immunity and Alters Susceptibility to Post-influenza Bacterial Superinfections
(2018-11)Influenza virus infections particularly when followed by bacterial superinfections (BSI) result in significant morbidities and mortalities especially during influenza pandemics. Type I interferons (IFNs) regulate both ... -
CD103 (aE integrin) undergoes endosomal trafficking in human dendritic cells, but does not mediate epithelial adhesion
(2018-12)Dendritic cell (DC) expression of CD103, the α subunit of αEβ7 integrin, is thought to enable DC interactions with E-cadherin-expressing gastrointestinal epithelia for improved mucosal immunosurveillance. In the stomach, ... -
The gut microbiome is required for full protection against acute arsenic toxicity in mouse models
(2018-12)Arsenic poisons an estimated 200 million people worldwide through contaminated food and drinking water. Confusingly, the gut microbiome has been suggested to both mitigate and exacerbate arsenic toxicity. Here, we show ... -
Impact of hydrologic boundaries on microbial planktonic and biofilm communities in shallow terrestrial subsurface environments
(2018-09)Subsurface environments contain a large proportion of planetary microbial biomass and harbor diverse communities responsible for mediating biogeochemical cycles important to groundwater used by human society for consumption, ... -
Detection of Pathogenic and Non-pathogenic Bacteria in Drinking Water and Associated Biofilms on the Crow Reservation, Montana, USA
(2018-07)Private residences in rural areas with water systems that are not adequately regulated, monitored, and updated could have drinking water that poses a health risk. To investigate water quality on the Crow Reservation in ... -
Expression and regulation of the Pseudomonas aeruginosa hibernation promoting factor
(2018-10)Bacterial biofilms contain subpopulations of cells that are dormant and highly tolerant to antibiotics. While dormant, the bacteria must maintain the integrity of macromolecules required for resuscitation. Previously, we ... -
Hypervirulent Group A Streptococcus of Genotype emm3 Invades the Vascular System in Pulmonary Infection of Mice
(2018-06)Natural mutations of the two-component regulatory system CovRS are frequently associated with invasive Group A Streptococcus (GAS) isolates and lead to the enhancement in virulence gene expression, innate immune evasion, ... -
Mechanisms of Mineral Substrate Acquisition in a Thermoacidophile
(2018-06)The thermoacidophile Acidianus is widely distributed in Yellowstone National Park hot springs that span large gradients in pH (1.60 to 4.84), temperature (42 to 90 degrees C), and mineralogical composition. To characterize ... -
Archaeal Viruses from High-Temperature Environments
(2018-02)Archaeal viruses are some of the most enigmatic viruses known, due to the small number that have been characterized to date. The number of known archaeal viruses lags behind known bacteriophages by over an order of magnitude. ... -
Multiple convergent supergene evolution events in mating-type chromosomes
(2018-05)Convergent adaptation provides unique insights into the predictability of evolution and ultimately into processes of biological diversification. Supergenes (beneficial gene linkage) are striking examples of adaptation, but ... -
Electron transfer to nitrogenase in different genomic and metabolic backgrounds
(2018-02)Nitrogenase catalyzes the reduction of dinitrogen (N2) using low potential electrons from ferredoxin (Fd) or flavodoxin (Fld) through an ATP dependent process. Since its emergence in an anaerobic chemoautotroph, this oxygen ... -
A PAX5-OCT4-PRDM1 developmental switch specifies human primordial germ cells
(2018-04)Dysregulation of genetic pathways during human germ cell development leads to infertility. Here, we analysed bona fide human primordial germ cells (hPGCs) to probe the developmental genetics of human germ cell specification ... -
Electron Acceptor Availability Alters Carbon and Energy Metabolism in a Thermoacidophile
(2018-05)The thermoacidophilic Acidianus strain DS80 displays versatility in its energy metabolism and can grow autotrophically and heterotrophically with elemental sulfur (S°), ferric iron (Fe3+) or oxygen (O2) as electron acceptors. ... -
Stable isotope probing of microbial iron reduction in Chocolate Pots hot spring, Yellowstone National Park
(2018-06)Chocolate Pots hot springs (CP) is a circumneutral pH, Fe-rich geothermal feature located in Yellowstone National Park. Previous Fe(III)-reducing enrichment culture studies with CP sediments identified close relatives of ...
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