Scholarly Work - Microbiology & Immunology
Recent Submissions
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Detection of Pathogenic and Non-pathogenic Bacteria in Drinking Water and Associated Biofilms on the Crow Reservation, Montana, USA
(2018-07)Private residences in rural areas with water systems that are not adequately regulated, monitored, and updated could have drinking water that poses a health risk. To investigate water quality on the Crow Reservation in ... -
Expression and regulation of the Pseudomonas aeruginosa hibernation promoting factor
(2018-10)Bacterial biofilms contain subpopulations of cells that are dormant and highly tolerant to antibiotics. While dormant, the bacteria must maintain the integrity of macromolecules required for resuscitation. Previously, we ... -
Hypervirulent Group A Streptococcus of Genotype emm3 Invades the Vascular System in Pulmonary Infection of Mice
(2018-06)Natural mutations of the two-component regulatory system CovRS are frequently associated with invasive Group A Streptococcus (GAS) isolates and lead to the enhancement in virulence gene expression, innate immune evasion, ... -
Mechanisms of Mineral Substrate Acquisition in a Thermoacidophile
(2018-06)The thermoacidophile Acidianus is widely distributed in Yellowstone National Park hot springs that span large gradients in pH (1.60 to 4.84), temperature (42 to 90 degrees C), and mineralogical composition. To characterize ... -
Archaeal Viruses from High-Temperature Environments
(2018-02)Archaeal viruses are some of the most enigmatic viruses known, due to the small number that have been characterized to date. The number of known archaeal viruses lags behind known bacteriophages by over an order of magnitude. ... -
Multiple convergent supergene evolution events in mating-type chromosomes
(2018-05)Convergent adaptation provides unique insights into the predictability of evolution and ultimately into processes of biological diversification. Supergenes (beneficial gene linkage) are striking examples of adaptation, but ... -
Electron transfer to nitrogenase in different genomic and metabolic backgrounds
(2018-02)Nitrogenase catalyzes the reduction of dinitrogen (N2) using low potential electrons from ferredoxin (Fd) or flavodoxin (Fld) through an ATP dependent process. Since its emergence in an anaerobic chemoautotroph, this oxygen ... -
A PAX5-OCT4-PRDM1 developmental switch specifies human primordial germ cells
(2018-04)Dysregulation of genetic pathways during human germ cell development leads to infertility. Here, we analysed bona fide human primordial germ cells (hPGCs) to probe the developmental genetics of human germ cell specification ... -
Electron Acceptor Availability Alters Carbon and Energy Metabolism in a Thermoacidophile
(2018-05)The thermoacidophilic Acidianus strain DS80 displays versatility in its energy metabolism and can grow autotrophically and heterotrophically with elemental sulfur (S°), ferric iron (Fe3+) or oxygen (O2) as electron acceptors. ... -
Stable isotope probing of microbial iron reduction in Chocolate Pots hot spring, Yellowstone National Park
(2018-06)Chocolate Pots hot springs (CP) is a circumneutral pH, Fe-rich geothermal feature located in Yellowstone National Park. Previous Fe(III)-reducing enrichment culture studies with CP sediments identified close relatives of ... -
Livestock abundance predicts vampire bat demography, immune profiles and bacterial infection risk
(2018-05)Human activities create novel food resources that can alter wildlife-pathogen interactions. If resources amplify or dampen, pathogen transmission probably depends on both host ecology and pathogen biology, but studies that ... -
Environmental persistence of influenza H5N1 is driven by temperature and salinity: insights from a Bayesian meta-analysis
(2018-09)Environmental persistence of zoonotic pathogens is a key trait that influences the probability of zoonotic spillover. Pathogen survival outside of the host determines the window available for contact with the new recipient ... -
Origin and Evolution of Flavin-Based Electron Bifurcating Enzymes
(2018-08)Twelve evolutionarily unrelated oxidoreductases form enzyme complexes that catalyze the simultaneous coupling of exergonic and endergonic oxidation–reduction reactions to circumvent thermodynamic barriers and minimize free ... -
Nevada Dust with Metals suppresses IgM antibodies
(2018)Systemic health effects from exposure to a complex natural dust containing heavy metalsfrom the Nellis Dunes Recreation Area (NDRA) near Las Vegas, NV, were evaluated. Several toxicological parameters were examined following ... -
The natural sesquiterpene lactones arglabin, grosheimin, agracin, parthenolide, and estafiatin inhibit T cell receptor (TCR) activation
(2018-02)Inhibition of the T cell receptor (TCR) pathway represents an effective strategy for the treatment of T cell-mediated inflammatory and autoimmune diseases. To identify natural compounds that could inhibit inflammatory T ... -
Synthesis and Biological Activity of Hydrazones of o- and p-Hydroxybenzoic Acids. Spatial Structure of 5-Bromo-2-hydroxybenzylidene-4-hydroxybenzohydrazide
(2017-10)A series of hydrazones based on hydrazides of o- and p-hydroxybenzoic acids have been prepared. N-(5-Bromo-2-hydroxybenzylidene)-4-hydroxybenzohydrazide has been studied by X-ray diffraction analysis; its molecule forms ... -
Cas1 and the Csy complex are opposing regulators of Cas2/3 nuclease activity
(2017-04)The type I-F CRISPR adaptive immune system in Pseudomonas aeruginosa (PA14) consists of two CRISPR loci and six CRISPR-associated (cas) genes. Type I-F systems rely on a CRISPR RNA (crRNA)-guided surveillance complex (Csy ... -
Persistent infections support maintenance of a coronavirus in a population of Australian bats (Myotis macropus)
(2017-07)Understanding viral transmission dynamics within populations of reservoir hosts can facilitate greater knowledge of the spillover of emerging infectious diseases. While bat-borne viruses are of concern to public health, ... -
Microbial Functional Gene Diversity Predicts Groundwater Contamination and Ecosystem Functioning
(2018-02)Contamination from anthropogenic activities has significantly impacted Earth\'s biosphere. However, knowledge about how environmental contamination affects the biodiversity of groundwater microbiomes and ecosystem functioning ... -
Synthesis and analytical characterization of new thiazol-2-(3H)-ones as human neutrophil elastase (HNE) inhibitors
(2018-01)Human neutrophil elastase (HNE) is a potent serine protease belonging to the chymotrypsin family and is involved in a variety of pathologies affecting the respiratory system. Thus, compounds able to inhibit HNE proteolytic ...
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