Scholarly Work - Microbiology & Immunology
Recent Submissions
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Stable isotope probing of microbial iron reduction in Chocolate Pots hot spring, Yellowstone National Park
(2018-06)Chocolate Pots hot springs (CP) is a circumneutral pH, Fe-rich geothermal feature located in Yellowstone National Park. Previous Fe(III)-reducing enrichment culture studies with CP sediments identified close relatives of ... -
Livestock abundance predicts vampire bat demography, immune profiles and bacterial infection risk
(2018-05)Human activities create novel food resources that can alter wildlife-pathogen interactions. If resources amplify or dampen, pathogen transmission probably depends on both host ecology and pathogen biology, but studies that ... -
Environmental persistence of influenza H5N1 is driven by temperature and salinity: insights from a Bayesian meta-analysis
(2018-09)Environmental persistence of zoonotic pathogens is a key trait that influences the probability of zoonotic spillover. Pathogen survival outside of the host determines the window available for contact with the new recipient ... -
Origin and Evolution of Flavin-Based Electron Bifurcating Enzymes
(2018-08)Twelve evolutionarily unrelated oxidoreductases form enzyme complexes that catalyze the simultaneous coupling of exergonic and endergonic oxidation–reduction reactions to circumvent thermodynamic barriers and minimize free ... -
Nevada Dust with Metals suppresses IgM antibodies
(2018)Systemic health effects from exposure to a complex natural dust containing heavy metalsfrom the Nellis Dunes Recreation Area (NDRA) near Las Vegas, NV, were evaluated. Several toxicological parameters were examined following ... -
The natural sesquiterpene lactones arglabin, grosheimin, agracin, parthenolide, and estafiatin inhibit T cell receptor (TCR) activation
(2018-02)Inhibition of the T cell receptor (TCR) pathway represents an effective strategy for the treatment of T cell-mediated inflammatory and autoimmune diseases. To identify natural compounds that could inhibit inflammatory T ... -
Synthesis and Biological Activity of Hydrazones of o- and p-Hydroxybenzoic Acids. Spatial Structure of 5-Bromo-2-hydroxybenzylidene-4-hydroxybenzohydrazide
(2017-10)A series of hydrazones based on hydrazides of o- and p-hydroxybenzoic acids have been prepared. N-(5-Bromo-2-hydroxybenzylidene)-4-hydroxybenzohydrazide has been studied by X-ray diffraction analysis; its molecule forms ... -
Cas1 and the Csy complex are opposing regulators of Cas2/3 nuclease activity
(2017-04)The type I-F CRISPR adaptive immune system in Pseudomonas aeruginosa (PA14) consists of two CRISPR loci and six CRISPR-associated (cas) genes. Type I-F systems rely on a CRISPR RNA (crRNA)-guided surveillance complex (Csy ... -
Persistent infections support maintenance of a coronavirus in a population of Australian bats (Myotis macropus)
(2017-07)Understanding viral transmission dynamics within populations of reservoir hosts can facilitate greater knowledge of the spillover of emerging infectious diseases. While bat-borne viruses are of concern to public health, ... -
Microbial Functional Gene Diversity Predicts Groundwater Contamination and Ecosystem Functioning
(2018-02)Contamination from anthropogenic activities has significantly impacted Earth\'s biosphere. However, knowledge about how environmental contamination affects the biodiversity of groundwater microbiomes and ecosystem functioning ... -
Synthesis and analytical characterization of new thiazol-2-(3H)-ones as human neutrophil elastase (HNE) inhibitors
(2018-01)Human neutrophil elastase (HNE) is a potent serine protease belonging to the chymotrypsin family and is involved in a variety of pathologies affecting the respiratory system. Thus, compounds able to inhibit HNE proteolytic ... -
Cigarette smoking is associated with an altered vaginal tract metabolomic profile
(2018-01)Cigarette smoking has been associated with both the diagnosis of bacterial vaginosis (BV) and a vaginal microbiota lacking protective Lactobacillus spp. As the mechanism linking smoking with vaginal microbiota and BV is ... -
Recently identified bee viruses and their impact on bee pollinators
(2018-02)Bees are agriculturally and ecologically important plant pollinators. Recent high annual losses of honey bee colonies, and reduced populations of native and wild bees in some geographic locations, may impact the availability ... -
Principles and Patterns of Bat Movements: From Aerodynamics to Ecology
(2017-09)Movement ecology as an integrative discipline has advanced associated fields because it presents not only a conceptual framework for understanding movement principles but also helps formulate predictions about the consequences ... -
H/D exchange mass spectrometry and statistical coupling analysis reveal a role for allostery in a ferredoxin-dependent bifurcating transhydrogenase catalytic cycle
(2018-01)Recent investigations into ferredoxin-dependent transhydrogenases, a class of enzymes responsible for electron transport, have highlighted the biological importance of flavin-based electron bifurcation (FBEB). FBEB generates ... -
Requirement and Synergistic Contribution of Platelet-Activating Factor Acetylhydrolase Sse and Streptolysin S to Inhibition of Neutrophil Recruitment and Systemic Infection by Hypervirulent emm3 Group A Streptococcus in Subcutaneous Infection of Mice
(2017-09)Hypervirulent group A streptococcus (GAS) can inhibit neutrophil recruitment and cause systemic infection in a mouse model of skin infection. The purpose of this study was to determine whether platelet-activating factor ... -
Interleukin 1α Is Critical for Resistance against Highly Virulent Aspergillus fumigatus Isolates
(2017-09)Heterogeneity among Aspergillus fumigatus isolates results in unique virulence potential and inflammatory responses. How these isolates drive specific immune responses and how this affects fungally induced lung damage and ... -
Conditions affecting the timing and magnitude of Hendra virus shedding across pteropodid bat populations in Australia
(2017-09)Understanding infection dynamics in animal hosts is fundamental to managing spillover and emergence of zoonotic infections. Hendra virus is endemic in Australian pteropodid bat populations and can be lethal to horses and ... -
Age-specific infectious period shapes dynamics of pneumonia in bighorn sheep
(2017-09)Superspreading, the phenomenon where a small proportion of individuals contribute disproportionately to new infections, has profound effects on disease dynamics. Superspreading can arise through variation in contacts, ... -
Influence of Growth Phase, pH, and Temperature on the Abundance and Composition of Tetraether Lipids in the Thermoacidophile Picrophilus torridus
(2016-08)The abundance and composition of glycerol dibiphytanyl glycerol tetraether (GDGT) and glycerol tribiphytanyl glycerol tetraether (GTGT) lipids were determined as a function of growth phase as a proxy for nutrient availability, ...
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