Recent Submissions

  • Elp1 is required for development of visceral sensory peripheral and central circuitry 

    Tolman, Zariah; Chaverra, Marta; George, Lynn; Lefcort, Frances (The Company of Biologists, 2022-05)
    Cardiovascular instability and a blunted respiratory drive in hypoxic conditions are hallmark features of the genetic sensory and autonomic neuropathy, familial dysautonomia (FD). FD results from a mutation in the gene ...
  • Investigating Abiotic and Biotic Mechanisms of Pyrite Reduction 

    Spietz, Rachel L.; Payne, Devon; Kulkarni, Gargi; Metcalf, William W.; Roden, Eric E.; Boyd, Eric S. (Frontiers Media SA, 2022-05)
    Pyrite (FeS2) has a very low solubility and therefore has historically been considered a sink for iron (Fe) and sulfur (S) and unavailable to biology in the absence of oxygen and oxidative weathering. Anaerobic methanogens ...
  • An ADAM17-Neutralizing Antibody Reduces Inflammation and Mortality While Increasing Viral Burden in a COVID-19 Mouse Model 

    Hedges, Jodi F.; Snyder, Deann T.; Robison, Amanda; Grifka-Walk, Heather M.; Blackwell, Karlin; Shepardson, Kelly; Kominsky, Douglas; Rynda-Apple, Agnieszka; Walcheck, Bruce; Jutila, Mark A. (Frontiers Media SA, 2022-06)
    Angiotensin Converting Enzyme 2 (ACE2) is the primary cell entry receptor for SARS-CoV and SARS-CoV-2 viruses. A disintegrin and metalloproteinase 17 (ADAM17) is a protease that cleaves ectodomains of transmembrane proteins, ...
  • Pyridazinones and Structurally Related Derivatives with Anti-Inflammatory Activity 

    Cantini, Niccolo; Schepetkin, Igor A.; Danilenko, Nadezhda V.; Khlebnikov, Andrei I.; Crocetti, Letizia; Giovannoni, Maria Paola; Kirpotina, Liliya N.; Quinn, Mark T. (MDPI AG, 2022-06)
    Persistent inflammation contributes to a number of diseases; therefore, control of the inflammatory response is an important therapeutic goal. In an effort to identify novel anti-inflammatory compounds, we screened a library ...
  • Transfer and persistence of bovine immunoglobulins in lambs fed a colostrum replacer 

    Johnson, Thea; Jacobson, Bryan Tegner; Jones, Kerri; Mosdal, Cassie; Jones, Steve; Vitkovic, Maia; Kruppenbacher, Sam; Sebrell, Andy; Bimczok, Diane (Wiley, 2022-07)
    Background. Colostrum-derived antibodies are crucial for the protection of newborn lambs from infectious diseases. Several colostrum replacer products that contain bovine antibodies are on the market. We investigated the ...
  • The Association Between Morningness-Eveningness Preference, Depression, Anxiety and Insomnia Among Chinese Textile Workers With or Without Shift Work 

    Jiang, Jiaqi; Wang, Dongfang; Scherffius, Andrew; Chen, Dingxuan; Ma, Zijuan; Chen, Zihao; Zhang, Yifan; Yu, Qian; Fan, Fang (Frontiers Media SA, 2022-06)
    Objective. Circadian preference and mental health disorders are closely related to insomnia. This study aimed to evaluate insomnia symptoms in textile factory workers with different work schedules, and to investigate the ...
  • Diversity of bacterial small RNAs drives competitive strategies for a mutual chaperone 

    Roca, Jorjethe; Santiago-Frangos, Andrew; Woodson, Sarah A. (Springer Science and Business Media LLC, 2022-05)
    Hundreds of bacterial small RNAs (sRNAs) require the Hfq chaperone to regulate mRNA expression. Hfq is limiting, thus competition among sRNAs for binding to Hfq shapes the proteomes of individual cells. To understand how ...
  • Encoding of small-scale air motion dynamics in the cricket, Acheta domesticus 

    Mulder-Rosi, Jonas; Miller, John P (American Physiological Society, 2022-03)
    The cercal sensory system of cricket mediates the detection, localization, and identification of air current signals generated by predators, mates, and competitors. This mechanosensory system has been used extensively for ...
  • Neutrophil Immunomodulatory Activity of Farnesene, a Component of Artemisia dracunculus Essential Oils 

    Schepetkin, Igor A.; Özek, Gulmira; Özek, Temel; Kirpotina, Liliya N.; Khlebnikov, Andrei I.; Klein, Robyn A.; Quinn, Mark T. (MDPI AG, 2022-05)
    Despite their reported therapeutic properties, not much is known about the immunomodulatory activity of essential oils present in Artemisia species. We isolated essential oils from the flowers and leaves of five Artemisia ...
  • Innate Immunomodulatory Activity of Cedrol, a Component of Essential Oils Isolated from Juniperus Species 

    Özek, Gulmira; Schepetkin, Igor A.; Yermagambetova, Moldir; Özek, Temel; Kirpotina, Liliya N.; Almerekova, Shyryn S.; Abugalieva, Saule I.; Khlebnikov, Andrei I.; Quinn, Mark T. (MDPI AG, 2021-12)
    Little is known about the immunomodulatory activity of essential oils isolated from Juniperus species. Thus, we isolated essential oils from the cones and leaves of eight juniper species found in Montana and in Kazakhstan, ...
  • Novel c-Jun N-Terminal Kinase (JNK) Inhibitors with an 11H-Indeno[1,2-b]quinoxalin-11-one Scaffold 

    Liakhov, Serhii A.; Schepetkin, Igor A.; Karpenko, Olexander S.; Duma, Hanna I.; Haidarzhy, Nadiia M.; Kirpotina, Liliya N.; Kovrizhina, Anastasia R.; Khlebnikov, Andrei I.; Bagryanskaya, Irina Y.; Quinn, Mark T. (MDPI AG, 2021-09)
    c-Jun N-terminal kinase (JNK) plays a central role in stress signaling pathways implicated in important pathological processes, including rheumatoid arthritis and ischemia-reperfusion injury. Therefore, inhibition of JNK ...
  • Therapeutic Effect of Novel Cyanopyrrolidine-Based Prolyl Oligopeptidase Inhibitors in Rat Models of Amnesia 

    Zolotov, Nikolay N.; Schepetkin, Igor A.; Voronina, Tatyana A.; Pozdnev, Vladimir F.; Khlebnikov, Andrei I.; Krylova, Irina V.; Quinn, Mark T. (Frontiers Media SA, 2021-12)
    Prolyl oligopeptidase (POP) is a large cytosolic serine peptidase that is altered in patients with Alzheimer’s disease, Parkinsonian syndrome, muscular dystrophies, and other denervating diseases. Thus, POP may represent ...
  • Vaginal microbiota of American Indian women and associations with measures of psychosocial stress 

    Borgogna, Joanna-Lynn C.; Anastario, Michael; Firemoon, Paula; Rink, Elizabeth; Ricker, Adriann; Ravel, Jacques; Brotman, Rebecca M.; Yeoman, Carl J. (Public Library of Science, 2021-12)
    Molecular-bacterial vaginosis (BV) is characterized by low levels of vaginal Lactobacillus species and is associated with higher risk of sexually transmitted infections (STI). Perceived psychosocial stress is associated ...
  • Host Lung Environment Limits Aspergillus fumigatus Germination through an SskA-Dependent Signaling Response 

    Kirkland, Marina E.; Stannard, McKenzie; Kowalski, Caitlin H.; Mould, Dallas; Caffrey-Carr, Alayna; Temple, Rachel M.; Ross, Brandon S.; Lofgren, Lotus A.; Stajich, Jason E.; Cramer, Robert A.; Obar, Joshua J. (American Society for Microbiology, 2021-12)
    Aspergillus fumigatus isolates display significant heterogeneity in growth, virulence, pathology, and inflammatory potential in multiple murine models of invasive aspergillosis. Previous studies have linked the initial ...
  • Comparison of Preservation and Extraction Methods on Five Taxonomically Disparate Coral Microbiomes 

    Pratte, Zoe A.; Kellogg, Christina A. (Frontiers Media SA, 2021-07)
    All animals are host to a multitude of microorganisms that are essential to the animal’s health. Host-associated microbes have been shown to defend against potential pathogens, provide essential nutrients, interact with ...
  • Elasmobranch microbiomes: emerging patterns and implications for host health and ecology 

    Perry, Cameron T.; Pratte, Zoe A.; Clavere-Graciette, Ana; Ritchie, Kim B.; Hueter, Robert E.; Newton, Alisa L.; Fischer, G. Christopher; Dinsdale, Elizabeth A.; Doane, Michael P.; Wilkinson, Krystan A.; Bassos-Hull, Kim; Lyons, Kady; Dove, Alistair D. M.; Hoopes, Lisa A.; Stewart, Frank J. (Springer Science and Business Media LLC, 2021-09)
    Elasmobranchs (sharks, skates and rays) are of broad ecological, economic, and societal value. These globally important fishes are experiencing sharp population declines as a result of human activity in the oceans. Research ...
  • Unexpected diversity of Endozoicomonas in deep-sea corals 

    Kellogg, CA; Pratte, ZA (Inter-Research Science Center, 2021-09)
    The deep ocean hosts a large diversity of azooxanthellate cold-water corals whose associated microbiomes remain to be described. While the bacterial genus Endozoicomonas has been widely identified as a dominant associate ...
  • Chemical Stimulants and Stressors Impact the Outcome of Virus Infection and Immune Gene Expression in Honey Bees (Apis mellifera) 

    Parekh, Fenali; Daughenbaugh, Katie F.; Flenniken, Michelle L. (Frontiers Media SA, 2021-10)
    Western honey bees (Apis mellifera) are ecologically, agriculturally, and economically important plant pollinators. High average annual losses of honey bee colonies in the US have been partially attributed to agrochemical ...
  • Ecology, evolution and spillover of coronaviruses from bats 

    Ruiz-Aravena, Manuel; McKee, Clifton; Gamble, Amandine; Lunn, Tamika; Morris, Aaron; Snedden, Celine E.; Yinda, Claude Kwe; Port, Julia R.; Buchholz, David W.; Yeo, Yao Yu; Faust, Christina; Jax, Elinor; Dee, Lauren; Jones, Devin N.; Kessler, Maureen K.; Falvo, Caylee; Crowley, Daniel; Bharti, Nita; Brook, Cara E.; Aguilar, Hector C.; Peel, Alison J.; Restif, Olivier; Schountz, Tony; Parrish, Colin R.; Gurley, Emily S.; Lloyd-Smith, James O.; Hudson, Peter J.; Munster, Vincent J.; Plowright, Raina K. (Springer Science and Business Media LLC, 2021-11)
    In the past two decades, three coronaviruses with ancestral origins in bats have emerged and caused widespread outbreaks in humans, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Since the first ...
  • Ecological dichotomies arise in microbial communities due to mixing of deep hydrothermal waters and atmospheric gas in a circumneutral hot spring. 

    Fernandes-Martins, Maria C.; Keller, Lisa M.; Munro-Ehrlich, Mason; Zimlich, Kathryn R.; Mettler, Madelyn K.; England, Alexis M.; Clare, Rita; Surya, Kevin; Shock, Everett L.; Colman, Daniel R.; Boyd, Eric S. (American Society for Microbiology, 2021-09)
    Understanding the source and availability of energy capable of supporting life in hydrothermal environments is central to predicting the ecology of microbial life on early Earth when volcanic activity was more widespread. ...

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