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dc.contributor.authorMiles, Mary
dc.contributor.authorFrederickson, Sara J.
dc.contributor.authorDepner, Chris M.
dc.contributor.authorKirwan, Rochelle D.
dc.date.accessioned2014-09-30T18:56:38Z
dc.date.available2014-09-30T18:56:38Z
dc.date.issued2010-10
dc.identifier.citationMiles MP, CM Depner, RD Kirwan, and SJ Frederickson. Influence of macronutrient intake and anthropometric characteristics on plasma insulin after eccentric exercise. Metabolism, Clinical and Experimental, 59:1456-1464, 2010.en_US
dc.identifier.issn0026-0495
dc.identifier.urihttp://dx.doi.org/10.1016/j.metabol.2010.01.010
dc.identifier.urihttps://scholarworks.montana.edu/xmlui/handle/1/3605
dc.description.abstractTo increase understanding of the interaction between macronutrients and insulin resistance (IR), this study sought to determine the influence of macronutrient intake and anthropometric differences on IR and inflammation responses to eccentric resistance exercise. Men and women (n = 12, 19-36 years old) participated in a crossover study and completed 6 sets of 10 unilateral maximal eccentric contractions of the elbow flexors and extensors followed by controlled diet conditions for the first 8 hours postexercise of carbohydrate/fat/protein proportions of either 75%/15%/10% (CHO) or 6%/70%/24% (FAT/PRO). Fasting glucose, insulin, homeostatic model assessment (HOMA) variables, and interleukin (IL)-1β were measured preexercise and 23 hours postexercise (additional measures of glucose and insulin 1 hour after meals consumed 0.5, 3, and 7 hours postexercise). Insulin increased more (P < .01) in the CHO compared with the FAT/PRO condition at 1.5, 4, and 8 hours postexercise. Insulin, HOMA-IR, and HOMA-β-cell function increased 23 hours postexercise in both conditions, whereas IL-1β increased 23 hours postexercise only in the CHO condition. Magnitude of change (Δ) for these variables associated positively with body mass index (BMI) and waist to hip ratio (WHR) in the CHO and inversely in the FAT/PRO condition; that is, r = 0.53 (P = .10) and r = −0.82 (P < .01) for BMI vs Δ insulin in CHO and FAT/PRO conditions, respectively. The Δ IL-1β associated with BMI (r = 0.62, P < .05) and WHR (r = 0.84, P < .01) in the CHO condition. The CHO enhanced IR and inflammation as BMI and WHR increased, whereas fat and protein enhanced IR as BMI and WHR decreased. Thus, BMI and WHR may need to be taken into account in the development of nutritional strategies to prevent IR.en_US
dc.description.sponsorshipThis study was funded by the Department of Health and Human Development at Montana State University and an ADVANCE Leadership grant from the National Science Foundation.en_US
dc.publisherW.B. Saunders Coen_US
dc.subjectHealth sciencesen_US
dc.titleInfluence of macronutrient intake and anthropometric characteristics on plasma insulin after eccentric exerciseen_US
dc.typeArticleen_US
mus.citation.extentfirstpage1456en_US
mus.citation.extentlastpage1464en_US
mus.citation.issue10en_US
mus.citation.journaltitleMetabolism, Clinical and Experimentalen_US
mus.citation.volume59en_US
mus.identifier.categoryHealth & Medical Sciencesen_US
mus.identifier.doi10.1016/j.metabol.2010.01.010en_US
mus.relation.collegeCollege of Education, Health & Human Developmenten_US
mus.relation.collegeCollege of Education, Health & Human Development
mus.relation.departmentHealth & Human Development.en_US
mus.relation.universityMontana State University - Bozemanen_US


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