College of Letters & Science: Recent submissions
Now showing items 1-20 of 985
-
In vivo hypoxia and a fungal alcohol dehydrogenase influence the pathogenesis of invasive pulmonary aspergillosis
(2011-07)Currently, our knowledge of how pathogenic fungi grow in mammalian host environments is limited. Using a chemotherapeutic murine model of invasive pulmonary aspergillosis (IPA) and 1H-NMR metabolomics, we detected ethanol ... -
SREBP coordinates iron and ergosterol homeostasis to mediate triazole drug and hypoxia responses in the human fungal pathogen Aspergillus fumigatus
(2011-12)Sterol regulatory element binding proteins (SREBPs) are a class of basic helix-loop-helix transcription factors that regulate diverse cellular responses in eukaryotes. Adding to the recognized importance of SREBPs in human ... -
Hepatocytes lacking thioredoxin reductase 1 have normal replicative potential during development and regeneration
(2010-07)Cells require ribonucleotide reductase (RNR) activity for DNA replication. In bacteria, electrons can flow from NADPH to RNR by either a thioredoxin-reductase- or a glutathione-reductase-dependent route. Yeast and plants ... -
Metagenomes from high-temperature chemotrophic systems reveal geochemical controls on microbial community structure and function
(2010-03)The Yellowstone caldera contains the most numerous and diverse geothermal systems on Earth, yielding an extensive array of unique high-temperature environments that host a variety of deeply-rooted and understudied Archaea, ... -
T. gondii RP promoters & knockdown reveal molecular pathways associated with proliferation and cell-cycle arrest
(2010-11)Molecular pathways regulating rapid proliferation and persistence are fundamental for pathogens but are not elucidated fully in Toxoplasma gondii. Promoters of T. gondii ribosomal proteins (RPs) were analyzed by EMSAs and ... -
Coordinated progression through two subtranscriptomes underlies the tachyzoitecycle of Toxoplasma gondii
(2010-08)Background Apicomplexan parasites replicate by varied and unusual processes where the typically eukaryotic expansion of cellular components and chromosome cycle are coordinated with the biosynthesis of parasite-specific ... -
Inducible bronchus-associated lymphoid tissue elicited by a protein cage nanoparticle enhances protection in mice against diverse respiratory viruses
(2009-09)Background Destruction of the architectural and subsequently the functional integrity of the lung following pulmonary viral infections is attributable to both the extent of pathogen replication and to the host-generated ... -
Cytoprotective Nrf2 pathway is induced in chronically txnrd 1-deficient hepatocytes
(2009-07)"Background Metabolically active cells require robust mechanisms to combat oxidative stress. The cytoplasmic thioredoxin reductase/thioredoxin (Txnrd1/Txn1) system maintains reduced protein dithiols and provides electrons ... -
Disruptions, Dislocations, and Inequalities: Latino Families Surviving the Global Economy
(2010-06)This Article draws on field research with Honduran and Mexican transnational families and the transnational family literature to explore how global inequality is influencing gender and class relations within poor migrant ... -
Pneumococcal surface protein A contributes to secondary Streptococcus pneumoniae infection after influenza virus infection
(2009-08)We compared the growth of Streptococcus pneumoniae mutants with a disruption in the gene for either pneumococcal surface protein A (PspA−), neuraminidase A (NanA−), or hyaluronidase (Hyl−) to that of the parental strain ... -
TmpL, a transmembrane protein required for intracellular redox homeostasis and virulence in a plant and an animal fungal pathogen
(2009-11)The regulation of intracellular levels of reactive oxygen species (ROS) is critical for developmental differentiation and virulence of many pathogenic fungi. In this report we demonstrate that a novel transmembrane protein, ... -
Something old, something new, something borrowed; how the thermoacidophilic archaeon Sulfolobus solfataricus responds to oxidative stress
(2009-09)To avoid molecular damage of biomolecules due to oxidation, all cells have evolved constitutive and responsive systems to mitigate and repair chemical modifications. Archaea have adapted to some of the most extreme ... -
HHsvm: Fast and accurate classification of profile-profile matches identified by HHsearch
(2009-12)Motivation: Recently developed profile–profile methods rival structural comparisons in their ability to detect homology between distantly related proteins. Despite this tremendous progress, many genuine relationships between ... -
Surface CO2 leakage during two shallow subsurface CO2 releases
(2007-12)A new field facility was used to study CO2 migration processes and test techniques to detect and quantify potential CO2 leakage from geologic storage sites. For 10 days starting 9 July 2007, and for seven days starting 3 ... -
Eddy covariance observations of surface leakage during shallow subsurface CO2 releases
(2009-06)We tested the ability of eddy covariance (EC) to detect, locate, and quantify surface CO2 flux leakage signals within a background ecosystem. For 10 days starting on 9 July 2007, and for 7 days starting on 3 August 2007, ... -
Effects of Climate-Related Stream Factors on Patterns of Individual Summer Growth of Cutthroat Trout
(2019-01)Coldwater fishes are sensitive to abiotic and biotic stream factors, which can be influenced by climate. Distributions of inland salmonids in North America have declined significantly, with many of the current strongholds ... -
Maladaptive nest-site selection by a sagebrush dependent species in a grazing-modified landscape
(2019-04)Animals are expected to select habitats that maximize their fitness over evolutionary time scales. Yet in human-modified landscapes, habitat selection might not always lead to increased fitness because animals undervalue ... -
Latino Health Perceptions in Rural Montana: Engaging Promotores de Salud Using Photovoice Through Facebook
(2019-04)The primary purposes of this study were to use photovoice with Facebook to explore health perceptions and health needs among promotores living in rural Montana and to build community among geographically dispersed promotores. ... -
Evidence of Microbursts Observed Near the Equatorial Plane in the Outer Van Allen Radiation Belt
(2018-08)We present the first evidence of electron microbursts observed near the equatorial plane in Earth’s outer radiation belt. We observed the microbursts on 31 March 2017 with the Magnetic Electron Ion Spectrometer and Radiation ... -
Microburst Scale Size Derived From Multiple Bounces of a Microburst Simultaneously Observed With the FIREBIRD-II CubeSats
(2018-09)We present the observation of a spatially large microburst with multiple bounces made simultaneously by the Focused Investigation of Relativistic Electron Bursts: Intensity, Range, and Dynamics II (FIREBIRD‐II) CubeSats ...
