Now showing items 1-20 of 24

    • Metabolic Responses Induced by Compression of Chondrocytes in Variable-Stiffness Microenvironments 

      McCutchen, Carley N.; Zignego, Donald L.; June, Ronald K. (2017-09)
      Cells sense and respond to mechanical loads in a process called mechanotransduction. These processes are disrupted in the chondrocytes of cartilage during joint disease. A key driver of cellular mechanotransduction is the ...
    • Mechanobiological implications of articular cartilage crystals 

      Carlson, Alyssa K.; McCutchen, Carley N.; June, Ronald K. (2017-03)
      PURPOSE OF REVIEW: Calcium crystals exist in both pathological and normal articular cartilage. The prevalence of these crystals dramatically increases with age, and crystals are typically found in osteoarthritic cartilage ...
    • Conditional Synaptic Vesicle Markers for Drosophila 

      Williams, Jessica L.; Shearin, Harold K.; Stowers, R. Steven (2019-01)
      The release of neurotransmitters from synaptic vesicles (SVs) at pre-synaptic release sites is the principle means by which information transfer between neurons occurs. Knowledge of the location of SVs within a neuron can ...
    • Reinterpretation of the substrate specificity of the voltage-sensing phosphatase during dimerization 

      Kruse, Martin; Kohout, Susy C.; Hille, Bertil (2019-02)
      Voltage-sensing phosphatases (VSPs) cleave both 3- and 5-phosphates from inositol phospholipids in response to membrane depolarization. When low concentrations of Ciona intestinalis VSP are expressed in Xenopus laevis ...
    • Saccades Trigger Predictive Updating of Attentional Topography in Area V4 

      Marino, Alexandria C.; Mazer, James A. (2018-04)
      During natural behavior, saccades and attention act together to allocate limited neural resources. Attention is generally mediated by retinotopic visual neurons; therefore, specific neurons representing attended features ...
    • Avian tail ontogeny, pygostyle formation, and interpretation of juvenile Mesozoic specimens 

      Rashid, Dana J.; Surya, Kevin; Chiappe, Luis M.; Carroll, Nathan; Garrett, Kimball L.; Varghese, Bino; Bailleul, Alida M.; O'Connor, Jingmai K.; Chapman, Susan C.; Horner, John R. (2018-06)
      The avian tail played a critical role in the evolutionary transition from long- to short-tailed birds, yet its ontogeny in extant birds has largely been ignored. This deficit has hampered efforts to effectively identify ...
    • Elongator and codon bias regulate protein levels in mammalian peripheral neurons 

      Goffena, Joy; Lefcort, Frances; Zhang, Yongqing; Lehrmann, Elin; Chaverra, Marta; Felig, Jehremy; Walters, Joseph; Buksch, Richard; Becker, Kevin G.; George, Lynn (2018-03)
      Familial dysautonomia (FD) results from mutation in IKBKAP/ELP1, a gene encoding the scaffolding protein for the Elongator complex. This highly conserved complex is required for the translation of codon-biased genes in ...
    • A PAX5-OCT4-PRDM1 developmental switch specifies human primordial germ cells 

      Fang, Fang; Angulo, Benjamin; Xia, Ninuo; Sukhwani, Meena; Wang, Zhengyuan; Carey, Charles C.; Mazurie, Aurélien J.; Cui, Jun; Wilkinson, Royce A.; Wiedenheft, Blake A.; Irie, Naoko; Surani, M. Azim; Orwig, Kyle E.; Reijo Pera, Renee A. (2018-04)
      Dysregulation of genetic pathways during human germ cell development leads to infertility. Here, we analysed bona fide human primordial germ cells (hPGCs) to probe the developmental genetics of human germ cell specification ...
    • Dimerization of the voltage-sensing phosphatase controls its voltage-sensing and catalytic activity 

      Rayaprolu, Vamseedhar; Royal, Perrine; Stengel, Karen; Sandoz, Guillaume; Kohout, Susy C. (2018-05)
      Multimerization is a key characteristic of most voltage-sensing proteins. The main exception was thought to be the Ciona intestinalis voltage-sensing phosphatase (Ci-VSP). In this study, we show that multimerization is ...
    • Changes in the stability and biomechanics of P22 bacteriophage capsid during maturation 

      Kant, Ravi; Llauro, Aida; Rayaprolu, Vamseedhar; Qazi, Shefah; de Pablo, Pedro J.; Douglas, Trevor; Bothner, Brian (2018-06)
      The capsid of P22 bacteriophage undergoes a series of structural transitions during maturation that guide it from spherical to icosahedral morphology. The transitions include the release of scaffold proteins and capsid ...
    • Neural crest development in Xenopus requires Protocadherin 7 at the lateral neural crest border 

      Rashid, Dana J.; Puettmann, Paul; Roy, Ethan; Bradley, Roger S. (2018-02)
      In vertebrates, the neural crest is a unique population of pluripotent cells whose development is dependent onsignalin g from neighbori ng tissues. Cadherin family members, including protocadherins, are emerging asmajor ...
    • Pediatric care during a short-term medical mission to a Syrian refugee camp in Northern Jordan 

      Abbott, Kenneth L.; Woods, Catherine A.; Halim, Dahlia A.; Qureshi, Henna A. (2017-12)
      Introduction The Syrian refugee crisis, now in its 6th year, has displaced millions. Refugees depend on support from host nation governments and humanitarian organizations like the Syrian American Medical Society (SAMS). ...
    • Women's perceptions of health, quality of life, and malaria management in Kakamega County, Western Province, Kenya 

      Dunkel, Florence V.; Hansen, Leanna M.; Halvorson, Sarah J.; Bangert, Arthur (2017-07)
      We assess women's perceptions of health risks in relation to quality of life concerns, with attention to variables viewed as central to maintaining or improving health and well-being. In this paper, we specifically underscore ...
    • Spatial working memory alters the efficacy of input to visual cortex 

      Merrikhi, Yaser; Clark, Kelsey; Albarran, Eddy; Parsa, Mohammadbagher; Zirnsak, Marc; Moore, Tirin; Noudoost, Behrad (2017-04)
      Prefrontal cortex modulates sensory signals in extrastriate visual cortex, in part via its direct projections from the frontal eye field (FEF), an area involved in selective attention. We find that working memory-related ...
    • Over Expression of NANOS3 and DAZL in Human Embryonic Stem Cells 

      Panula, Sarita; Reda, Ahmed; Stukenborg, Jan-Bernd; Ramathal, Cyril; Sukhwani, Meena; Albalushi, Halima; Edsgard, Daniel; Nakamura, Michiko; Soder, Olle; Orwig, Kyle E.; Yamanaka, Shinya; Reijo Pera, Renee A. (2016-10)
      The mechanisms underlying human germ cell development are largely unknown, partly due to the scarcity of primordial germ cells and the inaccessibility of the human germline to genetic analysis. Human embryonic stem cells ...
    • The Familial Dysautonomia disease gene, Ikbkap/Elp1, is required in the developing and adult central nervous system 

      Chaverra, Marta; George, Lynn; Mergy, Marc; Waller, Hannah R.; Kujawa, Katharine J.; Murnion, Connor; Sharples, Ezekiel; Thorne, Julian; Podgajny, Nathaniel; Grindeland, Andrea; Ueki, Yumi; Eiger, Steven; Cusick, Cassie; Babcock, A. Michael; Carlson, George A.; Lefcort, Frances (2017-02)
      Hereditary sensory and autonomic neuropathies (HSANs) are a genetically and clinically diverse group of disorders defined by peripheral nervous system (PNS) dysfunction. HSAN Type III, Familial Dysautonomia (FD), results ...
    • Experimental observation of phase-flip transitions in the brain 

      Dotson, Nicholas M; Gray, Charles M (2016-10)
      The phase-flip transition has been demonstrated in a host of coupled nonlinear oscillator models, many pertaining directly to understanding neural dynamics. However, there is little evidence that this phenomenon occurs in ...
    • The Drosophila prage Gene, Required for Maternal Transcript Destabilization in Embryos, Encodes a Predicted RNA Exonuclease 

      Cui, Jun; Lai, Yun Wei; Sartain, Caroline V.; Zuckerman, Rebecca M.; Wolfner, Mariana F. (2016-06)
      Egg activation, the transition of mature oocytes into developing embryos, is critical for the initiation of embryogenesis. This process is characterized by resumption of meiosis, changes in the egg's coverings and by ...
    • Quantification of dopaminergic neuron differentiation and neurotoxicity via a genetic reporter. 

      Cui, Jun; Rotstein, Megan; Bennett, Theo; Zhangm, Pengbo; Xia, Ninuo; Reijo Pera, Renee A. (2016-04)
      Human pluripotent stem cells provide a powerful human-genome based system for modeling human diseases in vitro and for potentially identifying novel treatments. Directed differentiation of pluripotent stem cells produces ...
    • TrkB/BDNF signalling patterns the sympathetic nervous system 

      Kasemeier-Kulesa, Jennifer S.; Morrison, Jason A.; Lefcort, Frances; Kulesa, Paul M. (2015-09)
      The sympathetic nervous system is essential for maintaining mammalian homeostasis. How this intricately connected network, composed of preganglionic neurons that reside in the spinal cord and post-ganglionic neurons that ...