Now showing items 21-40 of 95

    • Authors and editors assort on gender and geography in high-rank ecological publications 

      Manlove, Kezia R.; Belou, Rebecca M. (2018-02)
      Peer-reviewed publication volume and caliber are widely-recognized proxies for academic merit, and a strong publication record is essential for academic success and advancement. However, recent work suggests that publication ...
    • Meta-analysis of the Age-Dependent Efficacy of Multiple Sclerosis Treatments 

      Weideman, Ann Marie; Tapia-Maltos, Marco Aurelio; Johnson, Kory; Greenwood, Mark C.; Bielekova, Bibiana (2017-11)
      Objective: To perform a meta-analysis of randomized, blinded, multiple sclerosis (MS) clinical trials, to test the hypothesis that efficacy of immunomodulatory disease-modifying therapies (DMTs) on MS disability progression ...
    • New Multiple Sclerosis Disease Severity Scale Predicts Future Accumulation of Disability 

      Weideman, Ann Marie; Barbour, Christopher; Tapia-Maltos, Marco Aurelio; Tran, Tan; Jackson, Kayla; Kosa, Peter; Komori, Mika; Wichman, Alison; Johnson, Kory; Greenwood, Mark C.; Bielekova, Bibiana (2017-11)
      The search for the genetic foundation of multiple sclerosis (MS) severity remains elusive. It is, in fact, controversial whether MS severity is a stable feature that predicts future disability progression. If MS severity ...
    • Competitive resource allocation to metabolic pathways contributes to overflow metabolisms and emergent properties in cross-feeding microbial consortia 

      Carlson, Ross P.; Beck, Ashley E.; Phalak, Poonam; Fields, Matthew W.; Gedeon, Tomáš; Hanley, Luke; Harcombe, W. R.; Henson, Michael A.; Heys, Jeffrey J. (2018-04)
      Resource scarcity is a common stress in nature and has a major impact on microbial physiology. This review highlights microbial acclimations to resource scarcity, focusing on resource investment strategies for chemoheterotrophs ...
    • Surface micropattern reduces colonization and medical device-associated infections 

      Xu, Binjie; Wei, Qiuhua; Mettetal, M. Ryan; Han, Jie; Rau, Lindsey; Tie, Jinfeng; May, Rhea M.; Pathe, Eric T.; Reddy, Shravanthi T.; Sullivan, Lauren; Parker, Albert E.; Maul, Donald H.; Brennan, Anthony B.; Mann, Ethan E. (2017-11)
      PURPOSE: Surface microtopography offers a promising approach for infection control. The goal of this study was to provide evidence that micropatterned surfaces significantly reduce the potential risk of medical device-associated ...
    • Who Goes in and Out of the Hospital Patient Room? 

      Arbogast, James W.; Quinn, Jeff; Clark, Tracy; Moore, Lori; Thompson, Maria; Wagner, Pamela; Young, Elizabeth; Parker, Albert E. (2017-06)
      BACKGROUND: The objective of this study was to determine what percentage of entries and exits (E/E) in and out of the patient room should be attributed to healthcare workers (HCWs) in a wide variety of hospital units. This ...
    • Modelling radicalization: how small violent fringe sects develop into large indoctrinated societies 

      Short, Martin B.; McCalla, Scott G.; D'Orsogna, Maria R. (2017-08)
      We model radicalization in a society consisting of two competing religious, ethnic or political groups. Each of the \'sects\' is divided into moderate and radical factions, with intra-group transitions occurring either ...
    • Batalin-Vilkovisky quantization and the algebraic index 

      Grady, Ryan E.; Li, Qin; Li, Si (2017-09)
      Into a geometric setting, we import the physical interpretation of index theorems via semi-classical analysis in topological quantum field theory. We develop a direct relationship between Fedosov's deformation quantization ...
    • Accelerated Gibbs sampling of normal distributions using matrix splittings and polynomials 

      Fox, Colin; Parker, Albert E. (2017-11)
      Standard Gibbs sampling applied to a multivariate normal distribution with a specified precision matrix is equivalent in fundamental ways to the Gauss Seidel iterative solution of linear equations in the precision matrix. ...
    • The effects of interleukin-2 on immune response regulation 

      Waters, Ryan S.; Perry, Justin S. A.; Han, SunPil; Bielekova, Bibiana; Gedeon, Tomáš (2017-02)
      The immune system has many adaptive and dynamic components that are regulated to ensure appropriate, precise and rapid response to a foreign pathogen. A delayed or inadequate immune response can lead to prolonged disease, ...
    • Bioenergy and Breast Cancer: A report on tumor growth and metastasis 

      Running, Alice; Greenwood, Mark C.; Hildreth, Laura; Schmidt, Jade (2016)
      As many as 80% of the 296,000 women and 2,240 men diagnosed with breast cancer in the United States will seek out complementary and alternative medicine (CAM) treatments. One such therapy is Healing Touch (HT), recognized ...
    • A Mechanistic Model for Cooperative Behavior of Co-transcribing RNA Polymerases 

      Davis, Lisa; Gedeon, Tomáš; Heberling, Tamra; Gedeon, Jakub; Morgan, Charles (2016-08)
      In fast-transcribing prokaryotic genes, such as an rrn gene in Escherichia coli, many RNA polymerases (RNAPs) transcribe the DNA simultaneously. Active elongation of RNAPs is often interrupted by pauses, which has been ...
    • On the intrinsic dimensionality of chemical structure space 

      Veith, D.; Greenwood, B.; Hunter, R. S.; Niemi, G. J.; Regal, R. R. (1988-01)
      An important expectation in chemistry and pharmacology is that similar chemical structures have similar properties and behavior. New industrial chemicals, pesticides, and therapeutics are often sublte modifications of ...
    • Considerations for assessing model averaging of regression coefficients 

      Banner, Katharine Michelle; Higgs, Megan D. (2016-08)
      "Model choice is usually an inevitable source of uncertainty in model-based statistical analyses. While the focus of model choice was traditionally on methods for choosing a single model, methods to formally account for ...
    • Micropatterned Endotracheal Tubes Reduce Secretion-Related Lumen Occlusion 

      Mann, Ethan E.; Magin, Chelsea M.; Mettetal, M. Ryan; May, Rhea M.; Henry, MiKayla M.; DeLoid, Heather; Prater, Justin; Sullivan, Lauren; Thomas, John G.; Twite, Mark D.; Parker, Albert E.; Brennan, Anthony B.; Reddy, Shravanthi T. (2016-12)
      Tracheal intubation disrupts physiological homeostasis of secretion production and clearance, resulting in secretion accumulation within endotracheal tubes (ETTs). Novel in vitro and in vivo models were developed to ...
    • Combinatorial Representation of Parameter Space for Switching Networks 

      Cummins, Bree; Harker, Shaun; Mischaikow, Konstantin; Mok, Kafung; Gedeon, Tomáš (2016-11)
      We describe the theoretical and computational framework for the Dynamic Signatures Generated by Regulatory Networks (DSGRN) database. The motivation stems from an urgent need to understand the global dynamics of biologically ...
    • Global dynamics for steep nonlinearities in two dimensions 

      Gedeon, Tomáš; Harker, Shaun; Kokubu, Hiroshi; Mischaikow, Konstantin; Oka, Hiroe (2017-01)
      This paper discusses a novel approach to obtaining mathematically rigorous results on the global dynamics of ordinary differential equations. We study switching models of regulatory networks. To each switching network we ...
    • Symmetry breaking clusters in soft clustering decoding of neural codes 

      Parker, Albert E.; Dimitrov, Alexander G.; Gedeon, Tomáš (2010-02)
      Information-based distortion methods have been used successfully in the analysis of neural coding problems. These approaches allow the discovery of neural symbols and the corresponding stimulus space of a neuron or neural ...
    • When a habitat freezes solid: Microorganisms over-winter within the ice column of a coastal Antarctic lake 

      Foreman, Christine M.; Dieser, Markus; Greenwood, Mark C.; Cory, R. M.; Laybourn-Parry, Johanna; Lisle, John T.; Jaros, C.; Miller, P. L.; Chin, Yu-Ping; McKnight, Diane M. (2011-03)
      A major impediment to understanding the biology of microorganisms inhabiting Antarctic environments is the logistical constraint of conducting field work primarily during the summer season. However, organisms that persist ...
    • The mathematical structure of information bottleneck methods 

      Gedeon, Tomáš; Parker, Albert E.; Dimitrov, Alexander G. (2012-03)
      Information Bottleneck-based methods use mutual information as a distortion function in order to extract relevant details about the structure of a complex system by compression. One of the approaches used to generate optimal ...