Show simple item record

dc.contributor.advisorDratz, Edward
dc.contributor.advisorBowden, Jared
dc.contributor.authorBaker, Annelise
dc.date.accessioned2013-03-07T15:55:35Z
dc.date.available2013-03-07T15:55:35Z
dc.date.issued2013-03
dc.identifier.urihttps://scholarworks.montana.edu/xmlui/handle/1/724
dc.descriptionAbstract Onlyen_US
dc.description.abstractThe objective of the research is to assess the binding capacity of human serum albumin (HSA) in people with metabolic syndrome and type 2 diabetes (T2D), compared to healthy controls. The initial method uses the ability of the fluorescent compound 1-anilinonaphthalene-8-sulfonic acid (ANS) to be taken up on binding sites on HSA, where its fluorescence increases greatly when it is bound. The initial finding is that the plasma from a person with metabolic syndrome or T2D, when normalized for concentrations of HSA and ANS, will fluorescence significantly less than when compared to that of a person considered healthy. This is hypothesized to be due to some other molecule being bound to the HSA where ANS would normally bind. Metabolic syndrome is a precursor of T2D; searching samples from individuals in this pre-diabetic state should allow discovery of accurate predictive markers for T2D. This screening process could give a good indication of possible T2D and therefore the necessity of changing lifestyle or diet to prevent development of T2D and will help identify the currently unknown compounds that are partially filling the binding sites in HSA in the subjects.en_US
dc.language.isoen_USen_US
dc.titleA Screening Method of Hydrophobic Binding Capacity for Human Serum Albuminen_US
dc.typePresentationen_US
mus.citation.conferenceMSU Student Research Celebration 2012
mus.relation.collegeCollege of Nursing
mus.relation.departmentNursing.en_US
mus.relation.universityMontana State University - Bozemanen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record


MSU uses DSpace software, copyright © 2002-2017  Duraspace. For library collections that are not accessible, we are committed to providing reasonable accommodations and timely access to users with disabilities. For assistance, please submit an accessibility request for library material.