Scholarly Work - Chemistry & Biochemistry
Recent Submissions
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Structural Basis for the Mechanism of ATP-Dependent Acetone Carboxylation
(2017-08)Microorganisms use carboxylase enzymes to form new carbon-carbon bonds by introducing carbon dioxide gas (CO2) or its hydrated form, bicarbonate (HCO3 −), into target molecules. Acetone carboxylases (ACs) catalyze the ... -
Ultrafast Excited-State Deactivation of the Bacterial Pigment Violacein
(2017-08)The photophysical properties of the natural pigment violacein extracted from an Antarctic organism adapted to high exposure levels of UV radiation were measured in a combined steady-state and time-resolved spectroscopic ... -
X-ray crystallographic evidence for the simultaneous presence of axial and rhombic sites in cupredoxins: atomic resolution X-ray crystal structure analysis of pseudoazurin and DFT modelling
(2016-09)Crystal structure refinement of pseudoazurin from Achromobacter cycloclastes (AcPAz) was carried out at atomic (1.10 angstrom) resolution. The copper ion was localized in two positions at the metal binding site of AcPAz. ... -
Defining Electron Bifurcation in the Electron Transferring Flavoprotein Family
(2017-11)Electron bifurcation is the coupling of exergonic and endergonic redox reactions to simultaneously generate (or utilize) low and high potential electrons. It is the third recognized form of energy conservation in biology ... -
Structural Basis for the Mechanism of ATP-Dependent Acetone Carboxylation
(2017-08)Microorganisms use carboxylase enzymes to form new carbon-carbon bonds by introducing carbon dioxide gas (CO2) or its hydrated form, bicarbonate (HCO3-), into target molecules. Acetone carboxylases (ACs) catalyze the ... -
Unraveling the interactions of the physiological reductant flavodoxin with the different conformations of the Fe protein in the nitrogenase cycle
(2017-08)Nitrogenase reduces dinitrogen (N2) to ammonia in biological nitrogen fixation. The nitrogenase Fe protein cycle involves a transient association between the reduced, MgATP-bound Fe protein and the MoFe protein and includes ... -
Preparation and Evaluation of Potent PentafluorosulfanylSubstituted Anti-Tuberculosis Compounds
(2017-07)The global fight to stop tuberculosis (TB) remains a great challenge, particularly with the increase in drug-resistant strains and a lack of funding to support the development of new treatments. To bolster a precarious ... -
Indirect Interspecies Regulation: Transcriptional and Physiological Responses of a Cyanobacterium to Heterotrophic Partnership
(2017-03)The mechanisms by which microbes interact in communities remain poorly understood. Here, we interrogated specific interactions between photoautotrophic and heterotrophic members of a model consortium to infer mechanisms ... -
Differences in amino acid catabolism by gut microbes with/without prebiotics inclusion in GDDY-based diet affect feed utilization in rainbow trout
(2017-09)There is the need to enhance feed efficiency and growth of rainbow trout to reduce production costs of cultured fish. This study conducted a 3 × 4 factorial experiment with three graded levels of grain distiller dried yeast ... -
Proteomic and biochemical assays of glutathione-related proteins in susceptible and multiple herbicide resistant Avena fatua L.
(2017-06)Extensive herbicide usage has led to the evolution of resistant weed populations that cause substantial crop yield losses and increase production costs. The multiple herbicide resistant (MHR) Avena fatua L. populations ... -
Thermal stability as a determinant of AAV serotype identity
(2017-09)Currently, there are over 150 ongoing clinical trials utilizing adeno-associated viruses (AAVs) to target various genetic diseases, including hemophilia (AAV2 and AAV8), congenital heart failure (AAV1 and AAV6), cystic ... -
Multi-level Omics Analysis Provides Insight to the Ignicoccus hospitalis-Nanoarchaeum equitans Association
(2017-09)BACKGROUND Studies of interspecies interactions are inherently difficult due to the complex mechanisms which enable these relationships. A model system for studying interspecies interactions is the marine hyperthermophiles ... -
Blue-light induced accumulation of reactive oxygen species is a consequence of the Drosophila cryptochrome photocycle
(2017-03)Cryptochromes are evolutionarily conserved blue-light absorbing flavoproteins which participate in many important cellular processes including in entrainment of the circadian clock in plants, Drosophila and humans. Drosophila ... -
The Quantum Biology of Reactive Oxygen Species Partitioning Impacts Cellular Bioenergetics
(2016-12)Quantum biology is the study of quantum effects on biochemical mechanisms and biological function. We show that the biological production of reactive oxygen species (ROS) in live cells can be influenced by coherent electron ... -
Imaging theory of structured pump-probe microscopy
(2016-09)With sub-micron spatial resolution and femtosecond temporal resolution, pump probe microscopy provides a powerful spectroscopic probe of complex electronic environments in bulk and nanoscale materials. However, the electronic ... -
Surface Characterization of Mechanochemically Modified Exfoliated Halloysite Nanoscrolls
(2017-03)The surface modifications fundamentally influence the morphology of kaolinite nanostructures as a function of crystallinity and presence of contaminants. Beside morphology, the catalytic properties of 1:1-type exfoliated ... -
Optimized molecular structures for nanokaolinite dehydration and dehydroxylation toward the formation of nanometakaolinite [dataset]
(MSU ScholarWorks, 2017-03)The data depository contains XYZ atomic positional coordinates for all relevant structures to describe the dry-grinding, mechanochemical activation of nanokaolinite. During this process the kaolinite undergo dehydration, ... -
Decrease in pH destabilizes individual vault nanocages by weakening the inter-protein lateral interaction
(2016-10)Vault particles are naturally occurring proteinaceous cages with promising application as molecular containers. The use of vaults as functional transporters requires a profound understanding of their structural stability ... -
Altered stoichiometry Escherichia coli Cascade complexes with shortened CRISPR RNA spacers are capable of interference and primed adaptation
(2016-10)The Escherichia coli type I-E CRISPR-Cas system Cascade effector is a multisubunit complex that binds CRISPR RNA (crRNA). Through its 32-nucleotide spacer sequence, Cascade-bound crRNA recognizes protospacers in foreign ... -
Imidazo[1,2-a]Pyridine-3-Carboxamides Are Active Antimicrobial Agents against Mycobacterium avium Infection In Vivo.
(2016-08)A panel of six imidazo[1,2-a]pyridine-3-carboxamides (IAPs) were shown to have low-micromolar activity against Mycobacterium avium strains. Compound ND-10885 (compound 2) showed significant activity in the lung, spleen, ...
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