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  What Structural Features Make Porous Carbons Work for Redox-Enhanced Electrochemical Capacitors? A Fundamental Investigation 

  Zhao, Yang; Taylor, Erin E.; Hu, Xudong; Evanko, Brian; Zeng, Xiaojun; Wang, Hengbin; Ohnishi, Ryohji; Tsukazaki, Takaki; Li, Jian-Feng; Stadie, Nicholas P.; Yoo, Seung Joon; Stucky, Galen D.; Boettcher, Shannon W. (American Chemical Society, 2021-02)

  The addition of redox-active molecules into electrochemical-capacitor electrolytes provides increased specific energy density. Here we illustrate the underlying operational mechanisms and design principles for carbons with ...
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  Pseudomonas aeruginosa Planktonic- and Biofilm-Conditioned Media Elicit Discrete Metabolic Responses in Human Macrophages 

  Fuchs, Amanda; Miller, Isaac; Schiller, Sage; Ammons, Mary; Eilers, Brian; Tripet, Brian; Copie, Valerie (MDPI AG, 2020-10)

  Macrophages (MΦs) are prevalent innate immune cells, present throughout human bodily tissues where they orchestrate innate and adaptive immune responses to maintain cellular homeostasis. MΦs have the capacity to display a ...
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  Dual inhibition of the terminal oxidases eradicates antibiotic‐tolerant Mycobacterium tuberculosis 

  Lee, Bei Shi; Hards, Kiel; Engelhart, Curtis A.; Hasenoehrl, Erik J.; Kalia, Nitin P.; Mackenzie, Jared S.; Sviriaeva, Ekaterina; Chong, Shi Min Sherilyn; Manimekalai, Sony S.; Koh, Vanessa H.; Xu, Jiayong; Alonso, Sylvie; Miller, Marvin J.; Steyn, Adrie J.C.; Gruber, Gerhard; Schnappinger, Dirk; Berney, Michael; Cook, Gregory M.; Moraski, Garrett C.; Pethe, Kevin (EMBO, 2020-12)

  The approval of bedaquiline has placed energy metabolism in the limelight as an attractive target space for tuberculosis antibiotic development. While bedaquiline inhibits the mycobacterial F1F0 ATP synthase, small molecules ...
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  The flexible N-terminus of BchL autoinhibits activity through interaction with its [4Fe-4S] cluster and relieved upon ATP binding 

  Corless, Elliot I.; Imran, Syed Muhammad Saad; Watkins, Maxwell B.; Bacik, John-Paul; Mattice, Jenna; Patterson, Angela; Danyal, Karamatullah; Soffe, Mark; Kitelinger, Robert; Seefeldt, Lance C.; Origanti, Sofia S.; Bennett, Brian; Bothner, Brian; Ando, Nozomi; Antony, Edwin (Elsevier BV, 2020-11)

  A key step in bacteriochlorophyll biosynthesis is the reduction of protochlorophyllide to chlorophyllide, catalyzed by dark-operative protochlorophyllide oxidoreductase (DPOR). DPOR contains two [4Fe-4S]-containing component ...
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  Solvent Effects on the Selectivity of Palladium‐Catalyzed Suzuki‐Miyaura Couplings 

  Reeves, Emily K.; Bauman, Olivia R.; Mitchem, Gunner B.; Neufeldt, Sharon R. (Wiley, 2020-03)

  The use of polar solvents MeCN or dimethylformamide (DMF) was previously shown to induce a selectivity switch in the Pd/PtBu3-catalyzed Suzuki-Miyaura coupling of chloroaryl triflates. This phenomenon was attributed to the ...
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  Chemodivergence between Electrophiles in Cross‐Coupling Reactions 

  Reeves, Emily K.; Entz, Emily D.; Neufeldt, Sharon R. (Wiley, 2021-04)

  Chemodivergent cross-couplings are those in which either one of two (or more) potentially reactive functional groups can be made to react based on choice of conditions. In particular, this review focuses on cross-couplings ...
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  Pathways of Iron and Sulfur Acquisition, Cofactor Assembly, Destination, and Storage in Diverse Archaeal Methanogens and Alkanotrophs 

  Johnson, Christina; England, Alexis; Munro-Ehrlich, Mason; Colman, Daniel R.; DuBois, Jennifer L.; Boyd, Eric S. (2021-08)

  Archaeal methanogens, methanotrophs, and alkanotrophs have a high demand for iron (Fe) and sulfur (S); however, little is known of how they acquire, traffic, deploy, and store these elements. Here, we examined the distribution ...
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  NMR metabolomic analysis of bacterial resistance pathways using multivalent quaternary ammonium functionalized macromolecules 

  Aries, Michelle L.; Cloninger, Mary J. (2020-07)

  Introduction Multivalent antimicrobial dendrimers are an exciting new system that is being developed to address the growing problem of drug resistant bacteria. Nuclear Magnetic Resonance (NMR) metabolomics is a quantitative ...
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  Protein aggregation nucleated by functionalized dendritic polyglycerols 

  Bernhard, Samuel P.; Fricke, Mackenzie S.; Haag, Rainer; Cloninger, Mary J. (2020-06)

  Dendritic polyglycerols (dPGs) are emerging as important polymers for the study of biological processes due to their relatively low toxicity and excellent biocompatibility. The highly branched nature and high density of ...
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  Modification of PCL Scaffolds by Reactive Magnetron Sputtering: A Possibility for Modulating Macrophage Responses 

  Stankevich, Ksenia S.; Kudryavtseva, Valeriya L.; Bolbasov, Evgeny N.; Shesterikov, Evgeny V.; Larionova, Irina V.; Shapovalova, Yelena G.; Domracheva, Liubov V.; Volokhova, Apollinariya A.; Kurzina, Irina A.; Zhukov, Yuri M.; Malashicheva, Anna B.; Kzhyshkowska, Julia G.; Tverdokhlebov, Sergei I. (2020)

  Direct current (DC) reactive magnetron sputtering is as an efficient method for enhancing the biocompatibility of poly(ε-caprolactone) (PCL) scaffolds. However, the PCL chemical bonding state, the composition of the deposited ...
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  Oxygenated Aromatic Compounds are Important Precursors of Secondary Organic Aerosol in Biomass-Burning Emissions 

  Akherati, Ali; He, Yicong; Coggon, Matthew M.; Koss, Abigail; Hodshire, Anna; Sekimoto, Kanako; Warneke, Carsten; de Gouw, Joost A.; Yee, Lindsay D.; Seinfeld, John H.; Onasch, Timothy B.; Herndon, Scott C.; Knighton, Walter B.; Cappa, Christopher David; Kleeman, Michael J.; Yim, Christopher Y.; Kroll, Jesse H.; Pierce, Jeffrey R.; Jathar, Shantanu H. (2020)

  Biomass burning is the largest combustion-related source of volatile organic compounds (VOCs) to the atmosphere. We describe the development of a state-of-the-science model to simulate the photochemical formation of secondary ...
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  Physical and chemical mechanisms that influence the electrical conductivity of lignin-derived biochar 

  Kane, Seth; Ulrich, Rachel; Harrington, Abigail; Stadie, Nicholas P.; Ryan, Cecily (2021-10)

  Lignin-derived biochar is a promising, sustainable alternative to petroleum-based carbon powders (e.g., carbon black) for polymer composite and energy storage applications. Prior studies of these biochars demonstrate that ...
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  Adeno-Associated Virus (AAV) Capsid Stability and Liposome Remodeling During Endo/Lysosomal pH Trafficking 

  Lins-Austin, Bridget; Patel, Saajan; Mietzsch, Mario; Brooke, Dewey; Bennett, Antonette; Venkatakrishnan, Balasubramanian; Van Vliet, Kim; Smith, Adam N.; Long, Joanna R.; McKenna, Robert; Potter, Mark; Byrne, Barry; Boye, Sanford L.; Bothner, Brian; Heilbronn, Regine; Agbandje-McKenna, Mavis (2020-06)

  Adeno-associated viruses (AAVs) are small, non-pathogenic ssDNA viruses being used as therapeutic gene delivery vectors for the treatment of a variety of monogenic diseases. An obstacle to successful gene delivery is ...
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  Niche expansion for phototrophic sulfur bacteria at the Proterozoic - Phanerozoic transition 

  Cui, Xingqian; Liu, Xiao-Lei; Shen, Gaozhong; Ma, Jian; Husain, Fatima; Rocher, Donald; Zumberge, John E.; Bryant, Donald A.; Summons, Roger E. (2020-07)

  Fossilized carotenoid hydrocarbons provide a window into the physiology and biochemistry of ancient microbial phototrophic communities for which only a sparse and incomplete fossil record exists. However, accurate ...
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  Activity-based cell sorting reveals responses of uncultured archaea and bacteria to substrate amendment 

  Reichart, Nicholas J.; Jay, Zackary J.; Krukenberg, Viola; Parker, Albert E.; Spietz, Rachel L.; Hatzenpichler, Roland (2020)

  Metagenomic studies have revolutionized our understanding of the metabolic potential of uncultured microorganisms in various ecosystems. However, many of these genomic predictions have yet to be experimentally tested, and ...
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  Time-Dependent Fluorescence Spectroscopy to Quantify Complex Binding Interactions 

  Bernhard, Samuel P.; Goodman, Candace K.; Norton, Erienne G.; Alme, Daniel G.; Lawrence, C. Martin; Cloninger, Mary J. (2020-11)

  Measuring the binding affinity for proteins that can aggregate or undergo complex binding motifs presents a variety of challenges. In this study, fluorescence lifetime measurements using intrinsic tryptophan fluorescence ...
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  Short-Term Stable Isotope Probing of Proteins Reveals Taxa Incorporating Inorganic Carbon in a Hot Spring Microbial Mat 

  Steinke, Laurey; Slysz, Gordon; Lipton, Mary S.; Klatt, Christian; Moran, James J.; Romine, Margie F.; Wood, Jason M.; Anderson, Gordon; Bryant, Donald A.; Ward, David M. (2020-03)

  The upper green layer of the chlorophototrophic microbial mats associated with the alkaline siliceous hot springs of Yellowstone National Park consists of oxygenic cyanobacteria (Synechococcus spp.), anoxygenic Roseiflexus ...
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  Magnetron plasma mediated immobilization of hyaluronic acid for the development of functional double-sided biodegradable vascular graft 

  Kudryavtseva, Valeriya; Stankevich, Ksenia; Kozelskaya, Anna; Kibler, Elina; Zhukov, Yuri; Malashicheva, Anna; Golovkin, Alexey; Mishanin, Alexander; Filimonov, Victor; Bolbasov, Evgeny; Tverdokhlebov, Sergei (2020-11)

  The clinical need for vascular grafts is associated with cardiovascular diseases frequently leading to fatal outcomes. Artificial vessels based on bioresorbable polymers can replace the damaged vascular tissue or create a ...
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  Biosynthesis of the modified tetrapyrroles - the pigments of life 

  Bryant, Donald A.; Hunter, C. Neil; Warren, Martin J. (2021-01)

  Modified tetrapyrroles are large macrocyclic compounds, consisting of diverse conjugation and metal chelation systems and imparting an array of colors to the biological structures that contain them. Tetrapyrroles represent ...
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  Metabolic Implications of Using BioOrthogonal Non-Canonical Amino Acid Tagging (BONCAT) for Tracking Protein Synthesis 

  Steward, Katherine F.; Eilers, Brian J.; Tripet, Brian P.; Fuchs, Amanda; Dorle, Michael; Rawle, Rachel A.; Soriano, Berliza; Balasubramanian, Narayanaganesh; Copie, Valerie; Bothner, Brian; Hatzenpichler, Roland (2020-02)

  BioOrthogonal Non-Canonical Amino acid Tagging (BONCAT) is a powerful tool for tracking protein synthesis on the level of single cells within communities and whole organisms. A basic premise of BONCAT is that the non-canonical ...

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