Scholarly Work - Chemistry & Biochemistry
Recent Submissions
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Nickel-Catalyzed Stille Cross Coupling of C-O Electrophiles
(2019-04)Aryl sulfamates, tosylates, and mesylates undergo efficient Ni-catalyzed cross coupling with diverse organostannanes in the presence of relatively unhindered alkylphosphine ligands and KF. The coupling is valuable for ... -
Langmuir's Theory of Adsorption: A Centennial Review
(2019-04)The 100th anniversary of Langmuir's theory of adsorption is a significant landmark for the physical chemistry and chemical engineering communities. Despite its simplicity, the Langmuir adsorption model captures the key ... -
Dynamic processing of DOM: Insight from exometabolomics, fluorescence spectroscopy, and mass spectrometry
(2018-06)Dissolved organic matter (DOM) in freshwater environments is an important source of organic carbon, supporting bacterial respiration. Frozen environments cover vast expanses of our planet, with glaciers and ice-sheets ... -
The Prevalence of STIV c92-Like Proteins in Acidic Thermal Environments
(2011-05)A new type of viral-induced lysis system has recently been discovered for two unrelated archaeal viruses, STIV and SIRV2. Prior to the lysis of the infected host cell, unique pyramid-like lysis structures are formed on the ... -
Inducible bronchus-associated lymphoid tissue elicited by a protein cage nanoparticle enhances protection in mice against diverse respiratory viruses
(2009-09)Background Destruction of the architectural and subsequently the functional integrity of the lung following pulmonary viral infections is attributable to both the extent of pathogen replication and to the host-generated ... -
Something old, something new, something borrowed; how the thermoacidophilic archaeon Sulfolobus solfataricus responds to oxidative stress
(2009-09)To avoid molecular damage of biomolecules due to oxidation, all cells have evolved constitutive and responsive systems to mitigate and repair chemical modifications. Archaea have adapted to some of the most extreme ... -
Surface CO2 leakage during two shallow subsurface CO2 releases
(2007-12)A new field facility was used to study CO2 migration processes and test techniques to detect and quantify potential CO2 leakage from geologic storage sites. For 10 days starting 9 July 2007, and for seven days starting 3 ... -
Eddy covariance observations of surface leakage during shallow subsurface CO2 releases
(2009-06)We tested the ability of eddy covariance (EC) to detect, locate, and quantify surface CO2 flux leakage signals within a background ecosystem. For 10 days starting on 9 July 2007, and for 7 days starting on 3 August 2007, ... -
Using hyperspectral plant signatures for CO2 leak detection during the 2008 ZERT CO2 sequestration field experiment in Bozeman, MT
(2010-03)Hyperspectral plant signatures can be used as a short-term, as well as long-term (100-year timescale) monitoring technique to verify that CO2 sequestration fields have not been compromised. An influx of CO2 gas into the ... -
The catalytic mechanism of electron bifurcating electron transfer flavoproteins (ETFs) involves an intermediary complex with NAD
(2018-12)Electron bifurcation plays a key role in anaerobic energy metabolism but it is a relatively new discovery and only limited mechanistic information is available on the diverse enzymes that employ it. Herein, we focused on ... -
How a cofactor-free protein environment lowers the barrier to O2 reactivity
(2019-01)Molecular oxygen (O2)-utilizing enzymes are among the most important in biology. The abundance of O2, its thermodynamic power, and the benign nature of its end products have raised interest in oxidases and oxygenases for ... -
Light-Based 3D Printing of Hydrogels with High-Resolution Channels
(2019-01)Hydrogels are soft, water-based gels with widespread applications in personal care products, medicine and biomedical engineering. Many applications require structuring the hydrogel into complex three-dimensional (3D) shapes. ... -
Bulk Phosphorus-Doped Graphitic Carbon
(2018-07)A direct synthetic route to a tunable range of phosphorus-doped graphitic carbon materials is demonstrated via the reaction of benzene and phosphorus trichloride in a closed reactor at elevated temperatures (800-1050 degrees ... -
Exposure of Methicillin-Resistant Staphylococcus aureus to Low Levels of the Antibacterial THAM-3ΦG Generates a Small Colony Drug-Resistant Phenotype
(2018-06)This study investigated resistance against trishexylaminomelamine trisphenylguanide (THAM-3ΦG), a novel antibacterial compound with selective microbicidal activity against Staphylococcus aureus. Resistance development was ... -
Marsarchaeota are an aerobic archaeal lineage abundant in geothermal iron oxide microbial mats
(2018-05)The discovery of archaeal lineages is critical to our understanding of the universal tree of life and evolutionary history of the Earth. Geochemically diverse thermal environments in Yellowstone National Park provide ... -
Mechanism of N2 Reduction Catalyzed by Fe-Nitrogenase Involves Reductive Elimination of H2
(2018-02)Of the three forms of nitrogenase (Mo-nitrogenase, V-nitrogenase, and Fe-nitrogenase), Fe-nitrogenase has the poorest ratio of N2 reduction relative to H2 evolution. Recent work on the Mo-nitrogenase has revealed that ... -
Cyanobacteriochrome-based photoswitchable adenylyl cyclases (cPACs) for broad spectrum light regulation of cAMP levels in cells
(2018-06)Class III adenylyl cyclases generate the ubiquitous second messenger cAMP from ATP often in response to environmental or cellular cues. During evolution, soluble adenylyl cyclase catalytic domains have been repeatedly ... -
Hydrogen Deuterium Exchange Mass Spectrometry of Oxygen Sensitive Proteins
(2018-05)The protocol detailed here describes a way to perform hydrogen deuterium exchange coupled to mass spectrometry (HDX-MS) on oxygen sensitive proteins. HDX-MS is a powerful tool for studying the protein structure-function ... -
Curating viscoelastic properties of icosahedral viruses, virus-based nanomaterials, and protein cages
(2018-06)The beauty, symmetry, and functionality of icosahedral virus capsids has attracted the attention of biologists, physicists, and mathematicians ever since they were first observed. Viruses and protein cages assemble into ... -
Two-photon absorption spectra of fluorescent isomorphic DNA base analogs
(2018-01)Fluorescent DNA base analogs and intrinsic fluorophores are gaining importance for multiphoton microscopy and imaging, however, their quantitative nonlinear excitation properties have been poorly documented. Here we present ...
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