Scholarly Work - Chemistry & Biochemistry
Recent Submissions
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Enabling microbial syringol conversion through structure-guided protein engineering
(2019-07-19)Microbial conversion of aromatic compounds is an emerging and promising strategy for valorization of the plant biopolymer lignin. A critical and often rate-limiting reaction in aromatic catabolism is O-aryl-demethylation ... -
Zeolite-Templated Carbon as the Cathode for a High Energy Density Dual-Ion Battery
(2019-04)Dual-ion batteries (DIBs) are electrochemical energy storage devices that operate by the simultaneous participation of two different ion species at the anode and cathode and rely on the use of an electrolyte that can ... -
Characterization of synovial fluid metabolomic phenotypes of cartilage morphological changes associated with osteoarthritis
(2019-08)"Objective Osteoarthritis (OA) is a multifactorial disease with etiological heterogeneity. The objective of this study was to classify OA subgroups by generating metabolomic phenotypes from human synovial fluid. ... -
Ligation state of nickel during C-O bond activation with monodentate phosphines
(2018-11)The oxidative addition of phenolic electrophiles at Ni(0) in the presence of monodentate phosphine ligands was studied with both dispersion-free and dispersion-containing DFT methods. With the popular bulky ligand PCy3, ... -
N-Heterocyclic Carbene Ligand-Controlled Chemodivergent Suzuki–Miyaura Cross Coupling
(2019-09)Two N-heterocyclic carbene ligands provide orthogonal chemoselectivity during the Pd-catalyzed Suzuki–Miyaura (SM) cross-coupling of chloroaryl triflates. The use of SIPr [SIPr = 1,3-bis(2,6-diisopropylphenyl)-4,5-dihydr ... -
Carbon metabolism modulates the efficacy of drugs targeting the cytochrome bc1:aa3 in Mycobacterium tuberculosis
(2019-06)The influence of carbon metabolism on oxidative phosphorylation is poorly understood in mycobacteria. M. tuberculosis expresses two respiratory terminal oxidases, the cytochrome bc1:aa3 and the cytochrome bd oxidase, which ... -
Nickel-Catalyzed Stille Cross Coupling of C-O Electrophiles
(2019-04)Aryl sulfamates, tosylates, and mesylates undergo efficient Ni-catalyzed cross coupling with diverse organostannanes in the presence of relatively unhindered alkylphosphine ligands and KF. The coupling is valuable for ... -
Langmuir's Theory of Adsorption: A Centennial Review
(2019-04)The 100th anniversary of Langmuir's theory of adsorption is a significant landmark for the physical chemistry and chemical engineering communities. Despite its simplicity, the Langmuir adsorption model captures the key ... -
Dynamic processing of DOM: Insight from exometabolomics, fluorescence spectroscopy, and mass spectrometry
(2018-06)Dissolved organic matter (DOM) in freshwater environments is an important source of organic carbon, supporting bacterial respiration. Frozen environments cover vast expanses of our planet, with glaciers and ice-sheets ... -
The Prevalence of STIV c92-Like Proteins in Acidic Thermal Environments
(2011-05)A new type of viral-induced lysis system has recently been discovered for two unrelated archaeal viruses, STIV and SIRV2. Prior to the lysis of the infected host cell, unique pyramid-like lysis structures are formed on the ... -
Inducible bronchus-associated lymphoid tissue elicited by a protein cage nanoparticle enhances protection in mice against diverse respiratory viruses
(2009-09)Background Destruction of the architectural and subsequently the functional integrity of the lung following pulmonary viral infections is attributable to both the extent of pathogen replication and to the host-generated ... -
Something old, something new, something borrowed; how the thermoacidophilic archaeon Sulfolobus solfataricus responds to oxidative stress
(2009-09)To avoid molecular damage of biomolecules due to oxidation, all cells have evolved constitutive and responsive systems to mitigate and repair chemical modifications. Archaea have adapted to some of the most extreme ... -
Surface CO2 leakage during two shallow subsurface CO2 releases
(2007-12)A new field facility was used to study CO2 migration processes and test techniques to detect and quantify potential CO2 leakage from geologic storage sites. For 10 days starting 9 July 2007, and for seven days starting 3 ... -
Eddy covariance observations of surface leakage during shallow subsurface CO2 releases
(2009-06)We tested the ability of eddy covariance (EC) to detect, locate, and quantify surface CO2 flux leakage signals within a background ecosystem. For 10 days starting on 9 July 2007, and for 7 days starting on 3 August 2007, ... -
Using hyperspectral plant signatures for CO2 leak detection during the 2008 ZERT CO2 sequestration field experiment in Bozeman, MT
(2010-03)Hyperspectral plant signatures can be used as a short-term, as well as long-term (100-year timescale) monitoring technique to verify that CO2 sequestration fields have not been compromised. An influx of CO2 gas into the ... -
The catalytic mechanism of electron bifurcating electron transfer flavoproteins (ETFs) involves an intermediary complex with NAD
(2018-12)Electron bifurcation plays a key role in anaerobic energy metabolism but it is a relatively new discovery and only limited mechanistic information is available on the diverse enzymes that employ it. Herein, we focused on ... -
How a cofactor-free protein environment lowers the barrier to O2 reactivity
(2019-01)Molecular oxygen (O2)-utilizing enzymes are among the most important in biology. The abundance of O2, its thermodynamic power, and the benign nature of its end products have raised interest in oxidases and oxygenases for ... -
Light-Based 3D Printing of Hydrogels with High-Resolution Channels
(2019-01)Hydrogels are soft, water-based gels with widespread applications in personal care products, medicine and biomedical engineering. Many applications require structuring the hydrogel into complex three-dimensional (3D) shapes. ... -
Bulk Phosphorus-Doped Graphitic Carbon
(2018-07)A direct synthetic route to a tunable range of phosphorus-doped graphitic carbon materials is demonstrated via the reaction of benzene and phosphorus trichloride in a closed reactor at elevated temperatures (800-1050 degrees ... -
Exposure of Methicillin-Resistant Staphylococcus aureus to Low Levels of the Antibacterial THAM-3ΦG Generates a Small Colony Drug-Resistant Phenotype
(2018-06)This study investigated resistance against trishexylaminomelamine trisphenylguanide (THAM-3ΦG), a novel antibacterial compound with selective microbicidal activity against Staphylococcus aureus. Resistance development was ...
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