Scholarly Work - Chemistry & Biochemistry: Recent submissions
Now showing items 1-20 of 166
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Soluble CD4 and low molecular weight CD4-mimetic compounds sensitize cells to be killed by anti-HIV cytotoxic immunoconjugates
(American Society for Microbiology, 2023-09)The reservoir of HIV-infected cells that persist in the face of effective anti-retroviral therapy (ART) is the barrier to curing HIV infection. These long-lived CD4+ cells carry a functional provirus that can become activated ... -
Natural and anthropogenic carbon input affect microbial activity in salt marsh sediment
(Frontiers Media SA, 2023-09)Salt marshes are dynamic, highly productive ecosystems positioned at the interface between terrestrial and marine systems. They are exposed to large quantities of both natural and anthropogenic carbon input, and their ... -
Yeast Rad52 is a homodecamer and possesses BRCA2-like bipartite Rad51 binding modes
(Springer Science and Business Media LLC, 2023-10)Homologous recombination (HR) is an essential double-stranded DNA break repair pathway. In HR, Rad52 facilitates the formation of Rad51 nucleoprotein filaments on RPA-coated ssDNA. Here, we decipher how Rad52 functions ... -
Viruses of the Turriviridae: an emerging model system for studying archaeal virus-host interactions
(Frontiers Media SA, 2023-09)Viruses have played a central role in the evolution and ecology of cellular life since it first arose. Investigations into viral molecular biology and ecological dynamics have propelled abundant progress in our understanding ... -
Metabolic Phenotypes Reflect Patient Sex and Injury Status: A Cross-Sectional Analysis of Human Synovial Fluid
(Elsevier BV, 2023-09)Objective. Osteoarthritis is a heterogeneous disease. The objective was to compare differences in underlying cellular mechanisms and endogenous repair pathways between synovial fluid (SF) from male and female participants ... -
Anomalous Temperature and Polarization Dependences of Photoluminescence of Metal‐Organic Chemical Vapor Deposition‐Grown GeSe2
(Wiley, 2023-08)Germanium diselenide (GeSe2) is a 2D semiconductor with air stability, a wide bandgap, and anisotropic optical properties. The absorption and photoluminescence (PL) of single-crystalline 2D GeSe2 grown by metal-organic ... -
Structural insights into redox signal transduction mechanisms in the control of nitrogen fixation by the NifLA system
(Proceedings of the National Academy of Sciences, 2023-07)NifL is a conformationally dynamic flavoprotein responsible for regulating the activity of the σ54-dependent activator NifA to control the transcription of nitrogen fixation (nif) genes in response to intracellular oxygen, ... -
Base-Catalyzed Phenol-Mannich Condensation of Preformed Cesium Iminodiacetate. The Direct Synthesis of Calcein Blue AM and Related Acyloxymethyl Esters
(American Chemical Society, 2023-08)A rapid and highly practical one-flask procedure for the positionally selective preparation of (acyloxy)methyl N-(2-hydroxybenzyl)iminodiacetate and related diesters from iminodiacetic acid and phenols is described. The ... -
Hydrogen-Type Binding Sites in Carbonaceous Electrodes for Rapid Lithium Insertion
(American Chemical Society, 2023-08)Direct pyrolysis of coronene at 800 °C produces low-surface-area, nanocrystalline graphitic carbon containing a uniquely high content of a class of lithium binding sites referred to herein as “hydrogen-type” sites. ... -
Comparative genomics reveals electron transfer and syntrophic mechanisms differentiating methanotrophic and methanogenic archaea
(Public Library of Science, 2022-01)The anaerobic oxidation of methane coupled to sulfate reduction is a microbially mediated process requiring a syntrophic partnership between anaerobic methanotrophic (ANME) archaea and sulfate-reducing bacteria (SRB). Based ... -
An Aurora B-RPA signaling axis secures chromosome segregation fidelity
(Springer Science and Business Media LLC, 2023-05)Errors in chromosome segregation underlie genomic instability associated with cancers. Resolution of replication and recombination intermediates and protection of vulnerable single-stranded DNA (ssDNA) intermediates during ... -
Methanol Concentrations and Biological Methanol Consumption in the Northwest Pacific Ocean
(American Geophysical Union, 2023-04)Methanol metabolism can play an important role in marine carbon cycling. We made contemporaneous measurements of methanol concentration and consumption rates in the northwest Pacific Ocean to constrain the pathways and ... -
A Comprehensive NMR Analysis of Serum and Fecal Metabolites in Familial Dysautonomia Patients Reveals Significant Metabolic Perturbations
(MDPI AG, 2023-03)Central metabolism has a profound impact on the clinical phenotypes and penetrance of neurological diseases such as Alzheimer’s (AD) and Parkinson’s (PD) diseases, Amyotrophic Lateral Sclerosis (ALS) and Autism Spectrum ... -
Diversity and function of methyl-coenzyme M reductase-encoding archaea in Yellowstone hot springs revealed by metagenomics and mesocosm experiments
(Springer Science and Business Media LLC, 2023-03)Metagenomic studies on geothermal environments have been central in recent discoveries on the diversity of archaeal methane and alkane metabolism. Here, we investigated methanogenic populations inhabiting terrestrial ... -
Arsenic Exposure Causes Global Changes in the Metalloproteome of Escherichia coli
(MDPI AG, 2023-02)Arsenic is a toxic metalloid with differential biological effects, depending on speciation and concentration. Trivalent arsenic (arsenite, AsIII) is more toxic at lower concentrations than the pentavalent form (arsenate, ... -
Bacteroides thetaiotaomicron, a Model Gastrointestinal Tract Species, Prefers Heme as an Iron Source, Yields Protoporphyrin IX as a Product, and Acts as a Heme Reservoir
(Bacteroides thetaiotaomicron, a Model Gastrointestinal Tract Species, Prefers Heme as an Iron Source, Yields Protoporphyrin IX as a Product, and Acts as a Heme Reservoir, 2023-03)Members of the phylum Bacteroidetes are abundant in healthy gastrointestinal (GI) tract flora. Bacteroides thetaiotaomicron is a commensal heme auxotroph and representative of this group. Bacteroidetes are sensitive to ... -
1H NMR based metabolic profiling distinguishes the differential impact of capture techniques on wild bighorn sheep
(Springer Science and Business Media LLC, 2021-05)Environmental metabolomics has the potential to facilitate the establishment of a new suite of tools for assessing the physiological status of important wildlife species. A first step in developing such tools is to evaluate ... -
Copper deficiency is an independent risk factor for mortality in patients with advanced liver disease
(Ovid Technologies, 2023-01)Background and Aim: Copper is an essential trace metal serving as a cofactor in innate immunity, metabolism, and iron transport. We hypothesize that copper deficiency may influence survival in patients with cirrhosis through ... -
Stabilizing Effects of Phosphorus-Doped Silicon Nanoparticle Anodes in Lithium-Ion Batteries
(ACS Publications, 2023-01)Phosphorus-doped silicon has been reported to exhibit improved cycling stability and/or higher capacity retention than pure silicon as the anode in lithium-ion batteries. However, crystallite size and particle morphology ... -
Bispecific Anti-HIV Immunoadhesins That Bind Gp120 and Gp41 Have Broad and Potent HIV-Neutralizing Activity
(MDPI AG, 2021-07)We have constructed bispecific immunoglobulin-like immunoadhesins that bind to both the HIV-envelope glycoproteins: gp120 and gp41. These immunoadhesins have N terminal domains of human CD4 engrafted onto the N-terminus ...
