TrkB/BDNF signalling patterns the sympathetic nervous system
Kasemeier-Kulesa, Jennifer S.
Morrison, Jason A.
Kulesa, Paul M.
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The sympathetic nervous system is essential for maintaining mammalian homeostasis. How this intricately connected network, composed of preganglionic neurons that reside in the spinal cord and post-ganglionic neurons that comprise a chain of vertebral sympathetic ganglia, arises developmentally is incompletely understood. This problem is especially complex given the vertebral chain of sympathetic ganglia derive secondarily from the dorsal migration of â€˜primaryâ€™ sympathetic ganglia that are initially located several hundred microns ventrally from their future pre-synaptic partners. Here we report that the dorsal migration of discrete ganglia is not a simple migration of individual cells but a much more carefully choreographed process that is mediated by extensive interactions of pre-and post-ganglionic neurons. Dorsal migration does not occur in the absence of contact with preganglionic axons, and this is mediated by BDNF/TrkB signalling. Thus BDNF released by preganglionic axons acts chemotactically on TrkB-positive sympathetic neurons, to pattern the developing peripheral nervous system.
Kasemeier-Kulesa, Jennifer C., Jason A. Morrison, Frances Lefcort, and Paul M. Kulesa. "TrkB/BDNF signalling patterns the sympathetic nervous system." Nature Communications 6 (September 2015): 8281. DOI:https://dx.doi.org/10.1038/ncomms9281.