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dc.contributor.authorDe Leenheer, Patrick
dc.contributor.authorDockery, Jack D.
dc.contributor.authorGedeon, Tomas
dc.contributor.authorPilyugin, Sergei S.
dc.identifier.citationP. De Leenheer, J. Dockery, T. Gedeon and S. Pilyugin, “Senescence and antibiotic resistance in an age-structured population model”, J. Math. Biol., 61(4), pp. 475-499, (October 2010).en_US
dc.description.abstractDifferent theories have been proposed to understand the growing problem of antibiotic resistance of microbial populations. Here we investigate a model that is based on the hypothesis that senescence is a possible explanation for the existence of so-called persister cells which are resistant to antibiotic treatment. We study a chemostat model with a microbial population which is age-structured and show that if the growth rates of cells in different age classes are sufficiently close to a scalar multiple of a common growth rate, then the population will globally stabilize at a coexistence steady state. This steady state persists under an antibiotic treatment if the level of antibiotics is below a certain threshold; if the level exceeds this threshold, the washout state becomes a globally attracting equilibrium.en_US
dc.description.sponsorshipP. De Leenheer was supported in part by NSF grant DMS-0614651. T. Gedeon was supported in part by NSF grant DMS-0818785. S. S. Pilyugin was supported in part by NSF grant DMS-0818050.en_US
dc.titleSenescence and antibiotic resistance in an age-structured population modelen_US
mus.citation.journaltitleJournal of Mathematical Biologyen_US
mus.identifier.categoryHealth & Medical Sciencesen_US
mus.identifier.categoryLife Sciences & Earth Sciencesen_US
mus.identifier.categoryPhysics & Mathematicsen_US
mus.relation.collegeCollege of Letters & Scienceen_US
mus.relation.departmentMathematical Sciences.en_US
mus.relation.universityMontana State University - Bozemanen_US
mus.contributor.orcidGedeon, Tomas|0000-0001-5555-6741en_US

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