The history and market impact of CRISPR RNA-guided nucleases
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2015-06
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The interface between viruses and their hosts’ are hot spots for biological and biotechnological innovation. Bacteria use restriction endonucleases to destroy invading DNA, and industry has exploited these enzymes for molecular cut-and-paste reactions that are central to many recombinant DNA technologies. Today, another class of nucleases central to adaptive immune systems that protect bacteria and archaea from invading viruses and plasmids are blazing a similar path from basic science to profound biomedical and industrial applications.
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Van Erp, Paul BG, Gary Bloomer, Royce Wilkinson, and Blake Wiedenheft. “The History and Market Impact of CRISPR RNA-Guided Nucleases.” Current Opinion in Virology 12 (June 2015): 85–90. doi:10.1016/j.coviro.2015.03.011.