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dc.contributor.authorSchure, Mark B.
dc.contributor.authorBorson, Soo
dc.contributor.authorNguyen, Huong Q.
dc.contributor.authorTrittschuh, Emily H.
dc.contributor.authorThielke, Stephen M.
dc.contributor.authorPike, Kenneth C.
dc.contributor.authorAdams, Sandra G.
dc.contributor.authorFan, Vincent S.
dc.date.accessioned2016-08-09T13:59:12Z
dc.date.available2016-08-09T13:59:12Z
dc.date.issued2016-05
dc.identifier.citationSchure, Mark B. , Soo Borson, Huong Q. Nguyen, Emily H. Trittschuh, Stephen M. Thielke, Kenneth C. Pike, Sandra G. Adams, and Vincent S. Fan. "Associations of cognition with physical functioning and health-related quality of life among COPD patients." Respiratory Medicine 114 (May 2016): 46-52. DOI: 10.1016/j.rmed.2016.03.005.en_US
dc.identifier.issn0954-6111
dc.identifier.urihttps://scholarworks.montana.edu/xmlui/handle/1/9975
dc.description.abstractBackground: Neurocognitive impairment has been described in COPD patients, but little is known about its relationship with physical functioning and health-related quality of life (HRQL) in this chronically ill patient group. Methods: 301 stable COPD patients completed the Trail Making Test (TMT-A: psychomotor speed and TMT-B: executive control); 198 patients completed the Memory Impairment Screen (MIS). Standardization of TMT-A and TMT-B scores to a normative population yielded classifications of normal, borderline, or impaired cognitive status. Using multivariable regression, we examined the relationship between the TMT-A, TMT-B, and MIS with physical functioning (physical activity, 6-min walk test, and grip strength) and health-related quality of life (HRQL) measured with the Chronic Respiratory Questionnaire and the SF-36. Results: Nearly 30% of patients had either borderline or impaired cognition on the TMT-A or TMT-B. Adjusted models indicated that those with either borderline or impaired cognitive functioning had weaker grip strength (TMT-A borderline: β = −2.9, P < 0.05; TMT-B borderline: β = −3.0, P < 0.05; TMT-B impaired: β = −2.5, P < 0.05) and lower scores on the mental health component summary score (MCS-SF-36 HRQOL) measure (TMT-A impaired: β = −4.7, P < 0.01). No adjusted significant associations were found for other physical functioning measures or the other HRQL measures. Impaired memory showed a significant association only with the MCS scale. Conclusions: Cognitive function was not associated with most standard indicators of physical function or most measures of HRQL in COPD patients. Both TMT-A and TMT-B were associated with weaker grip strength, and the TMT-A and MIS with poorer mental health.en_US
dc.description.sponsorshipThis grant was funded by grant R01HL093146 from the National Heart, Lung, and Blood Institute (NHLBI); VA Postdoctoral Fellowship TPP 61-028.en_US
dc.titleAssociations of cognition with physical functioning and health-related quality of life among COPD patientsen_US
dc.typeArticleen_US
mus.citation.extentfirstpage46en_US
mus.citation.extentlastpage52en_US
mus.citation.journaltitleRespiratory Medicineen_US
mus.citation.volume114en_US
mus.identifier.categoryChemical & Material Sciencesen_US
mus.identifier.categoryHealth & Medical Sciencesen_US
mus.identifier.categorySocial Sciencesen_US
mus.identifier.doi10.1016/j.rmed.2016.03.005en_US
mus.relation.collegeCollege of Education, Health & Human Developmenten_US
mus.relation.departmentHealth & Human Development.en_US
mus.relation.universityMontana State University - Bozemanen_US
mus.data.thumbpage5en_US


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