Vaginal microbiota of American Indian women and associations with measures of psychosocial stress

dc.contributor.authorBorgogna, Joanna-Lynn C.
dc.contributor.authorAnastario, Michael
dc.contributor.authorFiremoon, Paula
dc.contributor.authorRink, Elizabeth
dc.contributor.authorRicker, Adriann
dc.contributor.authorRavel, Jacques
dc.contributor.authorBrotman, Rebecca M.
dc.contributor.authorYeoman, Carl J.
dc.date.accessioned2022-09-30T22:40:59Z
dc.date.available2022-09-30T22:40:59Z
dc.date.issued2021-12
dc.description.abstractMolecular-bacterial vaginosis (BV) is characterized by low levels of vaginal Lactobacillus species and is associated with higher risk of sexually transmitted infections (STI). Perceived psychosocial stress is associated with increased severity and persistence of infections, including STIs. American Indians have the highest rates of stress and high rates of STIs. The prevalence of molecular-BV among American Indian women is unknown. We sought to evaluate measures of psychosocial stress, such as historic loss (a multigenerational factor involving slavery, forced removal from one’s land, legally ratified race-based segregation, and contemporary discrimination) and their association with the vaginal microbiota and specific metabolites associated with BV, in 70 Northwestern Plains American Indian women. Demographics, perceived psychosocial stressors, sexual practices, and known BV risk factors were assessed using a modified version of the American Indian Service Utilization, Psychiatric Epidemiology, Risk and Protective Factors Project survey. Self-collected mid-vaginal swabs were profiled for bacterial composition by 16S rRNA gene amplicon sequencing and metabolites quantified by targeted liquid-chromatography mass spectrometry. Sixty-six percent of the participants were classified as having molecular-BV, with the rest being either dominated by L. crispatus (10%) or L. iners (24%). High levels of lifetime trauma were associated with higher odds of having molecular-BV (adjusted Odds Ratio (aOR): 2.5, 95% Credible Interval (CrI): 1.1–5.3). Measures of psychosocial stress, including historic loss and historic loss associated symptoms, were significantly associated with lifestyle and behavioral practices. Higher scores of lifetime trauma were associated with increased concentrations of spermine (aFC: 3.3, 95% CrI: 1.2–9.2). Historic loss associated symptoms and biogenic amines were the major correlates of molecular-BV. Historical loss associated symptoms and lifetime trauma are potentially important underlying factors associated with BV.en_US
dc.identifier.citationBorgogna J-LC, Anastario M, Firemoon P, Rink E, Ricker A, Ravel J, et al. (2021) Vaginal microbiota of American Indian women and associations with measures of psychosocial stress. PLoS ONE 16(12): e0260813. https://doi.org/ 10.1371/journal.pone.0260813en_US
dc.identifier.issn1932-6203
dc.identifier.urihttps://scholarworks.montana.edu/handle/1/17271
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.rightscc-byen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.subjectvaginal microbiotaen_US
dc.subjectamerican indian womenen_US
dc.subjectpsychosocial stressen_US
dc.titleVaginal microbiota of American Indian women and associations with measures of psychosocial stressen_US
dc.typeArticleen_US
mus.citation.extentfirstpage1en_US
mus.citation.extentlastpage26en_US
mus.citation.issue12en_US
mus.citation.journaltitlePLOS ONEen_US
mus.citation.volume16en_US
mus.data.thumbpage5en_US
mus.identifier.doi10.1371/journal.pone.0260813en_US
mus.relation.collegeCollege of Agricultureen_US
mus.relation.departmentMicrobiology & Cell Biology.en_US
mus.relation.universityMontana State University - Bozemanen_US

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
borgogna-psychosocial-2021.pdf
Size:
1.89 MB
Format:
Adobe Portable Document Format
Description:
vaginal microbiota psychosocial

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
826 B
Format:
Item-specific license agreed upon to submission
Description:
Copyright (c) 2002-2022, LYRASIS. All rights reserved.