Bacterial doubling time modulates the effects of opsonisation and available iron upon interactions between staphylococcus aureus and human neutrophils

dc.contributor.authorDomingue, Gill
dc.contributor.authorCosterton, J. William
dc.contributor.authorBrown, Michael R. W.
dc.date.accessioned2018-02-01T21:51:58Z
dc.date.available2018-02-01T21:51:58Z
dc.date.issued1996-12
dc.description.abstractStaphylococcus aureus was grown exponentially at two doubling times (DT), one related to in vivo (DT 60 min) and one typical of laboratory conditions (DT 24 min), and under iron-poor and iron-rich conditions. Relative to the fast-grown phenotypes, both slow-grown phenotypes exhibited low surface hydrophobicity and low protein A expression, induced poorly in non-opsonised and opsonised chemiluminescence, and survived well in whole blood killing. In particular, slow-grown, iron-poor cocci demonstrated enhanced survival in whole blood killing which correlated with a significant reduction in their association with polymorphonuclear leukocytes, compared to the three other phenotypes; iron sufficiency increased the ability to stimulate polymorphonuclear leukocytes irrespective of opsonisation status. Staphylococcal DT may, by influencing surface hydrophobicity, modify interactions with immune system components.en_US
dc.identifier.citationDomingue, G., J.W. Costerton, and M.R.W. Brown, "Bacterial doubling time modulates the effects of opsonisation and available iron upon interactions between staphylococcus aureus and human neutrophils," FEMS Immunology and Medical Microbiology, 16:223-228 (1996).en_US
dc.identifier.issn0928-8244
dc.identifier.urihttps://scholarworks.montana.edu/handle/1/14287
dc.titleBacterial doubling time modulates the effects of opsonisation and available iron upon interactions between staphylococcus aureus and human neutrophilsen_US
dc.typeArticleen_US
mus.citation.extentfirstpage223en_US
mus.citation.extentlastpage228en_US
mus.citation.issue3-4en_US
mus.citation.journaltitleFEMS Immunology and Medical Microbiologyen_US
mus.citation.volume16en_US
mus.data.thumbpage4en_US
mus.identifier.categoryEngineering & Computer Scienceen_US
mus.identifier.doi10.1111/j.1574-695x.1996.tb00139.xen_US
mus.relation.collegeCollege of Engineeringen_US
mus.relation.departmentCenter for Biofilm Engineering.en_US
mus.relation.departmentChemical & Biological Engineering.en_US
mus.relation.departmentChemical Engineering.en_US
mus.relation.researchgroupCenter for Biofilm Engineering.en_US
mus.relation.universityMontana State University - Bozemanen_US

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