C–O-Selective Cross-Coupling of Chlorinated Phenol Derivatives

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Date

2021-05

Journal Title

Journal ISSN

Volume Title

Publisher

Georg Thieme Verlag KG

Abstract

Chemoselective cross-coupling of phenol derivatives is valuable for generating products that retain halides. Here we discuss recent developments in selective cross-couplings of chloroaryl phenol derivatives, with a particular focus on reactions of chloroaryl tosylates. The first example of a C–O-selective Ni-catalyzed Suzuki–Miyaura coupling of chloroaryl tosylates is discussed in detail.1 Introduction2 Density Functional Theory Studies on Oxidative Addition at Nickel(0)3 Stoichiometric Oxidative Addition Studies4 Development of a Tosylate-Selective Suzuki Coupling5 Conclusion and Outlook

Description

This is the accepted manuscript version of an article published by Georg Thieme Verlag [C–O-Selective Cross-Coupling of Chlorinated Phenol Derivatives. Synlett 32, 15 p1484-1491 (2021)] https://doi.org/10.1055/a-1503-6330

Keywords

nickel, cross-coupling, oxidative addiction, chemoselectivity

Citation

Russell, J. E., & Neufeldt, S. R. (2021). C–O-Selective Cross-Coupling of Chlorinated Phenol Derivatives. Synlett, 32(15), 1484-1491.
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