Browsing by Author "Schleier, Jerome Joseph, III"

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Development of an environmental fate model for risk assessment of ultra-low-volume insecticides
(Montana State University - Bozeman, College of Agriculture, 2012) Schleier, Jerome Joseph, III; Chairperson, Graduate Committee: Robert K. D. Peterson.
One of the most effective ways of managing adult mosquitoes that vector human and animal pathogens is the use of ultra-low-volume (ULV) insecticides. The U.S. Environmental Protection Agency uses models that are not validated for ULV insecticide applications and exposure assumptions to perform their human and ecological risk assessments. Currently, there is no validated model that can accurately predict deposition of insecticides applied using ULV technology for adult mosquito management. In addition, little is known about the deposition and drift of small droplets like those used under conditions encountered during ULV applications. The objectives of my dissertation were to perform field studies to measure environmental concentrations of insecticides and to develop a validated model to predict the deposition of ULV insecticides, and use the data generated from the field study to perform refined human and aquatic ecological risk assessments. To model the field data collected during the summers of 2009-2011 a regression model selected by the Bayesian Information Criterion and k-fold cross validation was used to validate the selected model. k-fold cross validation demonstrated that the mean square error and mean square prediction error were similar indicating good predictive ability. The human-health risk assessment demonstrated that previous risk assessments used conservative exposure scenarios that overestimated risks, thus being conservative in protecting human health. Our results demonstrated a 10-fold reduction in the RQ estimates when comparing risk assessments using estimated environmental concentrations and actual environmental concentrations from the environmental fate model. Because I used a large data set to model concentrations deposited on surfaces, this variance in exposure is due to the inherent variability in deposition concentrations after ULV applications and, therefore, would not warrant further refinement to improve risk assessments. The aquatic risk assessment using actual environmental concentrations showed that the 95th percentile estimated concentration would result in less than 0.0001% of the potentially affected fraction of species reaching their respective LC50. Our results are supported by the weight of evidence that pyrethroids applied by ground-based ULV applications will not result in deleterious effects on aquatic organisms.
Environmental concentrations, fate, and risk assessment of insecticides used for adult mosquito management
(Montana State University - Bozeman, College of Agriculture, 2008) Schleier, Jerome Joseph, III; Chairperson, Graduate Committee: Robert K. D. Peterson.
One of the most effective ways of managing adult mosquitoes that vector human and animal pathogens is the use of ultra-low-volume (ULV) insecticides. Due to a lack of studies examining the environmental fate of ULV insecticides and because previous risk assessments have shown that environmental concentrations of insecticides contributed the largest amount of variance to the estimated total exposure, I measured deposition onto surfaces and air concentrations of permethrin and naled. I also conducted risk assessments for human and other non-target organisms using the values I measured. Deposition concentrations of permethrin and naled generally decreased as distance from the spray source increased. Overall, approximately 3.2% of the permethrin and 15% of the naled applied deposited on the ground within 75 m from the spray source 1 h after application. Concentrations of permethrin and naled 12 h after application were not significantly different than concentrations 1 h after application. The results of my probabilistic human-health risk assessment using actual environmental concentrations showed that previous risk assessments overestimated risks. Thus they were conservative in protecting human health. The non-target risk assessment and field bioassay using the house cricket, Acheta domesticus (L.), as a surrogate for medium- to large-bodied ground dwelling insects showed that ULV applications most likely would not result in impacts on populations. I also measured actual environmental concentrations of pyrethrins and piperonyl butoxide (PBO) after aerial ULV applications. Pyrethrins were not detected in the water or on deposition pads. However PBO was detected in the water and on deposition samples, but concentrations rapidly decreased to background levels by 36 h after application. The estimated risks of pyrethrins and PBO to aquatic surrogates were lower than those estimated by previous ecological risk assessments. My study is the first to relate actual environmental concentrations of ULV insecticides to estimates of human-health risks. Results of my environmental fate studies, human-health and non-target risk assessments, and the current weight of scientific evidence, demonstrate that the risks to humans and the environment after ULV applications of insecticides most likely are below regulatory levels of concern.