Theses and Dissertations at Montana State University (MSU)
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Item The synthesis and reactions of some small platinum cluster compounds(Montana State University - Bozeman, College of Letters & Science, 1989) Min, DongItem Synthesis, characterization, and biological evaluation of platinum IV complexes exhibiting anticancer properties(Montana State University - Bozeman, College of Letters & Science, 1989) Edwards, Wayne RossThe chemotherapeutic agent cisplatin is widely used in the treatment of head, neck, ovarian, testicular and bladder cancers. The major disadvantages in using cisplatin are its low solubility and high toxicity, in particular nephrotoxicity. These two limitations prevent cisplatin from being administrated at higher concentrations than 1.0 mg/Kg. Fifteen platinum IV compounds were synthesized and characterized by NMR. Nine of the 15 were soluble enough in Fetal Bovine Serum to be evaluated in a tissue culture assay using murine B-16 melanoma and Lewis Lung carcinoma cells. Toxicity and chemotherapeutic activity in tumor bearing mice was used to evaluate those compounds showing high solubility and chemotherapeutic activity in tissue culture. Only one of the nine compounds showed high solubility and chemotherapeutic activity in the assay. The toxicity of this compound,11, using C57B1 mice was determined to be LD50 >41 mg/Kg, compared to cisplatins' LD50 of 13-14 mg/Kg. The compound was evaluated for its chemotherapeutic effects in tumor bearing mice and it was found to give a dose response against the B-16 melanoma tumor. Of the other compounds tested in the tissue culture assay one in particular showed significant activity, 20. The LD100 was 29 μM while cisplatin and dichloro-(ethylenediamine)Pt(II) were 15 microns and 75 microns respectively. It was discovered that dicarboxylates substituents increased the solubility of platina(IV)cylcobutanes more so than alcohols, ethers and aldehydes. Amine platinum ligands influenced the chemotherapeutic activity, with ethylenediamine complexes showing more activity than either pyridine or 2,2'-dipyridine complexes.Item Preparation and reactions of platina(IV) cyclobutanes and the first platinum(IV)-bound olefin from bicyclo[n.1.0]hydrocarbons(Montana State University - Bozeman, College of Letters & Science, 1986) Parsons, Edith JaneItem Decomposition of diazoalkanes by platinum(II) olefins(Montana State University - Bozeman, College of Letters & Science, 1986) Hanks, Timothy WayneItem Structure and chemical reactivity of selected platinacyclobutanes(Montana State University - Bozeman, College of Letters & Science, 1985) Ekeland, Robert AlanItem Synthesis, characterization, and mechanistic studies on a group of platinum complexes using 195PT nuclear magnetic resonance(Montana State University - Bozeman, College of Letters & Science, 1991) Bedgood, Danny RichardItem Chemistry of Platina(IV)cyclobutanes derived from acenaphthalene, 1,4-epoxy-1,4-dihydronaphthalene, benzonorbornene, and substituted and unsubstituted, norbornenes, and norbornadienes(Montana State University - Bozeman, College of Letters & Science, 1990) Moats, Rex A.Item A study of polymeric platinum(II) compounds and Nanoscale materials(Montana State University - Bozeman, College of Letters & Science, 2004) Anderson, Bernard Marshall; Chairperson, Graduate Committee: Edwin H. Abbott; Lee H. Spangler (co-chair)The photophysical and structural properties of the tetra-u- pyrophosphitodiplatinate (2-) anion have been well studied in the past. One such analogue of this compound is a phosphorescent red compound of unknown structure. A new synthesis route has been was found for both the tetra-u- pyrophosphitodiplatinate (2-) and the red anionic compounds. By synthesizing the pyrophosphorus ligand outright and reacting that with tetrachloroplatinate (2-) either the tetra-u-pyrophosphitodiplatinate (2-) or the red anionic compounds can be synthesized depending on the amount of the phosphorus acid that is present. It was found from light scattering measurements and with the usage of 31P NMR spectroscopy that the red platinum(II) compound is structurally different than that of tetra-u-pyrophosphitodiplatinate (2-). A revised synthetic route was made for the synthesis of pyrophosphorus acid which was found to be an insoluble, highly reactive ligand. Reactions of pyrophosphorus acid with normal alcohols led to the formation of phosphorus acid and the corresponding monoalkylated phosphorus acid.