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Item Interplay of plant pathogens and host defenses: Unveiling the mechanisms and strategies for crop protection(Agriculture and Environmental Science Academy, 2024-03) Poudel, Amrit; KC, ShreejanaPlant pathogens, encompassing a diverse array of microbes including fungi, nematodes, protozoa, bacteria, and viruses, represent a significant threat to agricultural stability by compromising plant health. These microorganisms engage in a complex battle against plant immune systems, leading to diseases that can drastically diminish crop yields, degrade product quality, and in extreme cases, cause total crop failure. A comprehensive understanding of the mechanisms underlying plant infection, the specific pathogens involved, and the strategy for effective prevention is crucial for agricultural sustainability. This review paper provides a detailed examination of the multifaceted interactions between plant pathogens and their hosts, focusing on the entry mechanisms, symptom development, and prevention strategies against plant diseases. Major findings reveal the intricate ways pathogens interact with plant immune responses, the critical role of environmental factors in disease outbreaks, and the effectiveness of integrated disease management approaches. The paper concludes with a novel perspective, emphasizing the urgent need for sustainable, science-based strategies to enhance plant resistance, safeguard food security, and mitigate the economic consequences of plant pathogenic diseases. This synthesis not only advances our understanding of plant pathology but also sets a framework for future research directions in plant disease management.