Adaptive responses to antimicrobial agents in biofilms

dc.contributor.authorSzomolay, Barbara
dc.contributor.authorKlapper, Isaac
dc.contributor.authorDockery, Jack D.
dc.contributor.authorStewart, Philip S.
dc.date.accessioned2017-07-19T22:45:54Z
dc.date.available2017-07-19T22:45:54Z
dc.date.issued2005-08
dc.description.abstractBacterial biofilms demonstrate adaptive resistance in response to antimicrobial stress more effectively than corresponding planktonic populations. We propose here that, in biofilms, reaction-diffusion limited penetration may result in only low levels of antimicrobial exposure to deeper regions of the biofilm. Sheltered cells are then able to enter an adapted resistant state if the local time scale for adaptation is faster than that for disinfection. This mechanism is not available to a planktonic population. A mathematical model is presented to illustrate. Results indicate that, for a sufficiently thick biofilm, cells in the biofilm implement adaptive responses more effectively than do freely suspended cells. Effective disinfection requires applied biocide concentration that increases quadratically or exponentially with biofilm thickness.en_US
dc.identifier.citationSzomolay B, Klapper I, Dockery J, Stewart PS, "Adaptive responses to antimicrobial agents in biofilms," Environ Microbiol, 2005 7(8):1186-1191en_US
dc.identifier.issn1462-2912
dc.identifier.urihttps://scholarworks.montana.edu/handle/1/13349
dc.titleAdaptive responses to antimicrobial agents in biofilmsen_US
dc.typeArticleen_US
mus.citation.extentfirstpage1186en_US
mus.citation.extentlastpage1191en_US
mus.citation.issue8en_US
mus.citation.journaltitleEnvironmental Microbiologyen_US
mus.citation.volume7en_US
mus.contributor.orcidStewart, Philip S.|0000-0001-7773-8570en_US
mus.data.thumbpage5en_US
mus.identifier.categoryEngineering & Computer Scienceen_US
mus.identifier.doi10.1111/j.1462-2920.2005.00797.xen_US
mus.relation.collegeCollege of Engineeringen_US
mus.relation.departmentCenter for Biofilm Engineering.en_US
mus.relation.departmentChemical & Biological Engineering.en_US
mus.relation.departmentChemical Engineering.en_US
mus.relation.researchgroupCenter for Biofilm Engineering.en_US
mus.relation.universityMontana State University - Bozemanen_US

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