A computer investigation of chemically mediated detachment in bacterial biofilms

dc.contributor.authorHunt, Stephen Michael
dc.contributor.authorHamilton, Martin A.
dc.contributor.authorSears, Joe
dc.contributor.authorHarkin, Gary
dc.contributor.authorReno, Jason
dc.date.accessioned2017-08-16T22:34:24Z
dc.date.available2017-08-16T22:34:24Z
dc.date.issued2003-05
dc.description.abstractA three-dimensional computer model was used to evaluate the effect of chemically mediated detachment on biofilm development in a negligible-shear environment. The model, BacLAB, combines conventional diffusion-reaction equations for chemicals with a cellular automata algorithm to simulate bacterial growth, movement and detachment. BacLAB simulates the life cycle of a bacterial biofilm from its initial colonization of a surface to the development of a mature biofilm with cell areal densities comparable to those in the laboratory. A base model founded on well established transport equations that are easily adaptable to investigate conjectures at the biological level has been created. In this study, the conjecture of a detachment mechanism involving a bacterially produced chemical detachment factor in which high local concentrations of this detachment factor cause the bacteria to detach from the biofilm was examined. The results show that the often observed ‘mushroom’-shaped structure can occur if detachment events create voids so that the remaining attached cells look like mushrooms.en_US
dc.identifier.citationHunt, S.M., M.A. Hamilton, J.T. Sears, G. Harkin, and J. Reno, "A computer investigation of chemically mediated detachment in bacterial biofilms," Microbiology, 149:1155-1163 (2003).en_US
dc.identifier.issn1350-0872
dc.identifier.urihttps://scholarworks.montana.edu/handle/1/13532
dc.titleA computer investigation of chemically mediated detachment in bacterial biofilmsen_US
dc.typeArticleen_US
mus.citation.extentfirstpage1155en_US
mus.citation.extentlastpage1163en_US
mus.citation.issue5en_US
mus.citation.journaltitleMicrobiologyen_US
mus.citation.volume149en_US
mus.data.thumbpage7en_US
mus.identifier.categoryEngineering & Computer Scienceen_US
mus.identifier.doi10.1099/mic.0.26134-0en_US
mus.relation.collegeCollege of Engineeringen_US
mus.relation.departmentCenter for Biofilm Engineering.en_US
mus.relation.departmentChemical & Biological Engineering.en_US
mus.relation.departmentChemical Engineering.en_US
mus.relation.researchgroupCenter for Biofilm Engineering.en_US
mus.relation.universityMontana State University - Bozemanen_US

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