NMR Relaxometry to Characterize the Drug Structural Phase in a Porous Construct
| dc.contributor.author | Thrane, Linn W. | |
| dc.contributor.author | Berglund, Emily A. | |
| dc.contributor.author | Wilking, James N. | |
| dc.contributor.author | Vodak, David | |
| dc.contributor.author | Seymour, Joseph D. | |
| dc.date.accessioned | 2019-01-28T21:11:26Z | |
| dc.date.available | 2019-01-28T21:11:26Z | |
| dc.date.issued | 2018-06 | |
| dc.description.abstract | Nuclear magnetic resonance (NMR) frequency spectra and T2 relaxation time measurements, using a high-power radio frequency probe, are shown to characterize the presence of an amorphous drug in a porous silica construct. The results indicate the ability of non-solid-state NMR methods to characterize crystalline and amorphous solid structural phases in drugs. Two-dimensional T1–T2 magnetic relaxation time correlation experiments are shown to monitor the impact of relative humidity on the drug in a porous silica tablet. | en_US |
| dc.identifier.citation | Thrane, Linn W., Emily A. Berglund, James N. Wilking, David Vodak, and Joseph D. Seymour, “NMR Relaxometry to Characterize the Drug Structural Phase in a Porous Construct,” Molecular Pharmaceutics, June 2018; 15(7): 2614-2620. doi: 10.1021/acs.molpharmaceut.8b00144 | en_US |
| dc.identifier.issn | 1543-8392 | |
| dc.identifier.uri | https://scholarworks.montana.edu/handle/1/15177 | |
| dc.language.iso | en | en_US |
| dc.rights | This Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). | en_US |
| dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | en_US |
| dc.title | NMR Relaxometry to Characterize the Drug Structural Phase in a Porous Construct | en_US |
| dc.type | Article | en_US |
| mus.citation.extentfirstpage | 2614 | en_US |
| mus.citation.extentlastpage | 2620 | en_US |
| mus.citation.issue | 7 | en_US |
| mus.citation.journaltitle | Molecular Pharmaceutics | en_US |
| mus.citation.volume | 15 | en_US |
| mus.data.thumbpage | 6 | en_US |
| mus.identifier.category | Engineering & Computer Science | en_US |
| mus.identifier.doi | 10.1021/acs.molpharmaceut.8b00144 | en_US |
| mus.relation.college | College of Engineering | en_US |
| mus.relation.department | Center for Biofilm Engineering. | en_US |
| mus.relation.researchgroup | Center for Biofilm Engineering. | en_US |
| mus.relation.university | Montana State University - Bozeman | en_US |
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