A three-dimensional computer model of four hypothetical mechanisms protecting biofilms from antimicrobials

dc.contributor.authorChambless, Jason Daniel
dc.contributor.authorHunt, Stephen Michael
dc.contributor.authorStewart, Philip S.
dc.date.accessioned2017-07-13T22:24:02Z
dc.date.available2017-07-13T22:24:02Z
dc.date.issued2006-03
dc.description.abstractFour hypothetical mechanisms for protection of biofilms against antimicrobials were incorporated into a three-dimensional model of biofilm growth and development. The model integrated processes of substrate utilization, diffusion, growth, cell migration, death, and detachment in a cellular automaton framework. Compared to simulations of unprotected biofilms, each of the protective mechanisms provided some tolerance to antimicrobial action. When the mechanisms were compared to each other, the behaviors of the four protective mechanisms produced distinct shapes of killing curves, non-uniform spatial patterns of survival and cell type distribution, and anticipated susceptibility patterns for dispersed biofilm cells. The differences between the protective mechanisms predicted in these simulations could guide the design of experiments to discriminate antimicrobial tolerance mechanisms in biofilms. Each of the mechanisms could be a plausible avenue of biofilm protection.en_US
dc.identifier.citationChambless JD, Hunt SM, Stewart PS, "A three-dimensional computer model of four hypothetical mechanisms protecting biofilms from antimicrobials," Appl Environ Microbiol 2006 72(3):2005-2013en_US
dc.identifier.issn0099-2240
dc.identifier.urihttps://scholarworks.montana.edu/handle/1/13294
dc.titleA three-dimensional computer model of four hypothetical mechanisms protecting biofilms from antimicrobialsen_US
dc.typeArticleen_US
mus.citation.extentfirstpage2005en_US
mus.citation.extentlastpage2013en_US
mus.citation.issue3en_US
mus.citation.journaltitleApplied and Environmental Microbiologyen_US
mus.citation.volume72en_US
mus.contributor.orcidStewart, Philip S.|0000-0001-7773-8570en_US
mus.data.thumbpage3en_US
mus.identifier.categoryEngineering & Computer Scienceen_US
mus.identifier.doi10.1128/aem.72.3.2005-2013.2006en_US
mus.relation.collegeCollege of Engineeringen_US
mus.relation.departmentCenter for Biofilm Engineering.en_US
mus.relation.departmentChemical & Biological Engineering.en_US
mus.relation.departmentChemical Engineering.en_US
mus.relation.researchgroupCenter for Biofilm Engineering.en_US
mus.relation.universityMontana State University - Bozemanen_US

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