The prevalence of biofilms in chronic wounds: a systematic review and meta-analysis of published data

dc.contributor.authorMalone, Matthew
dc.contributor.authorBjarnsholt, Thomas
dc.contributor.authorMcBain, Andrew J.
dc.contributor.authorJames, Garth A.
dc.contributor.authorStoodley, Paul
dc.contributor.authorLeaper, David
dc.contributor.authorTachi, Masahiro
dc.contributor.authorSchultz, Gregory
dc.contributor.authorSwanson, Terry
dc.contributor.authorWolcott, Randall D.
dc.date.accessioned2017-06-16T19:30:22Z
dc.date.available2017-06-16T19:30:22Z
dc.date.issued2017-01
dc.description.abstractThe presence of biofilms in chronic non-healing wounds, has been identified through in vitro model and in vivo animal data. However, human chronic wound studies are under-represented and generally report low sample sizes. For this reason we sought to ascertain the prevalence of biofilms in human chronic wounds by undertaking a systematic review and meta-analysis. Our initial search identified 554 studies from the literature databases (Cochrane Library, Embase, Medline). After removal of duplicates, and those not meeting the requirements of inclusion, nine studies involving 185 chronic wounds met the inclusion criteria. Prevalence of biofilms in chronic wounds was 78.2 % (confidence interval [CI 61.6-89, p<0.002]). The results of our meta-analysis support our clinical assumptions that biofilms are ubiquitous in human chronic non-healing wounds.en_US
dc.identifier.citationMalone M, Barjnsholt T, McBain AJ, James GA, Stoodley P, Leaper D, Tachi M, Shultz G, Swanson T, Wolcott RD “The prevalence of biofilms in chronic wounds: A systematic review and meta-analysis of published data” Journal of Wound Care, 2017 Jan 2;26(1):20-25.en_US
dc.identifier.issn0969-0700
dc.identifier.urihttps://scholarworks.montana.edu/handle/1/13068
dc.titleThe prevalence of biofilms in chronic wounds: a systematic review and meta-analysis of published dataen_US
dc.typeArticleen_US
mus.citation.extentfirstpage20en_US
mus.citation.extentlastpage25en_US
mus.citation.issue1en_US
mus.citation.journaltitleJournal of Wound Careen_US
mus.citation.volume26en_US
mus.contributor.orcidStoodley, Paul|0000-0001-6069-273Xen_US
mus.data.thumbpage5en_US
mus.identifier.categoryEngineering & Computer Scienceen_US
mus.identifier.doi10.12968/jowc.2017.26.1.20en_US
mus.relation.collegeCollege of Engineeringen_US
mus.relation.departmentCenter for Biofilm Engineering.en_US
mus.relation.departmentChemical & Biological Engineering.en_US
mus.relation.researchgroupCenter for Biofilm Engineering.en_US
mus.relation.universityMontana State University - Bozemanen_US

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