Multiscale Flux-Based Modeling of Biofilm Communities

dc.contributor.authorZhang, T.
dc.contributor.authorParker, A.
dc.contributor.authorCarlson, R.P.
dc.contributor.authorStewart, Philip S.
dc.contributor.authorKlapper, I.
dc.date.accessioned2022-04-14T20:08:21Z
dc.date.available2022-04-14T20:08:21Z
dc.date.issued2020-01
dc.description.abstractModels of microbial community dynamics generally rely on a subscale description for microbial metabolisms. In systems such as distributed multispecies communities like biofilms, where it may not be reasonable to simplify to a small number of limiting substrates, tracking the large number of active metabolites likely requires measurement or estimation of large numbers of kinetic and regulatory parameters. Alternatively, a largely kinetics-free framework is proposed combining cellular level constrained, steady state flux analysis of metabolism with macroscale microbial community models. This multiscale setup naturally allows coupling of macroscale information, including measurement data, with cell scale metabolism. Further, flexibility in methodology is stressed: choices at the microscale (e.g., flux balance analysis or elementary flux modes) and at the macroscale (e.g., physical-chemical influences relevant to biofilm or planktonic environments) are available to the user. Illustrative computations in the context of a biofilm, including comparisons of systemic and Nash equilibration as well as an example of coupling experimental data into predictions, are provided.en_US
dc.identifier.citationZhang, T., Parker, A., Carlson, R. P., Stewart, P. S., & Klapper, I. (2020). Multiscale Flux-Based Modeling of Biofilm Communities. Multiscale Modeling & Simulation, 18(2), 1025–1052. https://doi.org/10.5281/zenodo.6321242en_US
dc.identifier.issn1540-3459
dc.identifier.urihttps://scholarworks.montana.edu/handle/1/16728
dc.language.isoen_USen_US
dc.publisherSociety for Industrial & Applied Mathematicsen_US
dc.titleMultiscale Flux-Based Modeling of Biofilm Communitiesen_US
dc.typeArticleen_US
mus.citation.extentfirstpage1025en_US
mus.citation.extentlastpage1052en_US
mus.citation.issue2en_US
mus.citation.journaltitleMultiscale Modeling & Simulationen_US
mus.citation.volume18en_US
mus.identifier.doi10.5281/zenodo.6321242en_US
mus.relation.collegeCollege of Engineeringen_US
mus.relation.departmentCenter for Biofilm Engineering.en_US
mus.relation.departmentMathematical Sciences.en_US
mus.relation.researchgroupCenter for Biofilm Engineering.en_US
mus.relation.universityMontana State University - Bozemanen_US

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