Bacterial biofilm inhibitors from Diospyros dendo

Abstract

One new (1) and four known (2-5) ursene triterpenes with potent inhibition of the formation of the bacterial biofilm Pseudomonas aeruginosa PA01 were obtained from Diospyros dendo using a high-throughput natural products chemistry procedure. These compounds were isolated as mass-limited samples. The miniaturization of the structure elucidation and dereplication was performed primarily utilizing a capillary-scale NMR probe. Y-SL, Le NT, O'Neil-Johnson M, Costerton JW, Eldridge GR," Bacterial biofilm inhibitors from Diospyros dendo," J Nat Prod, 2006; 69(1):118-120